{"id":770,"date":"2014-09-12T11:45:42","date_gmt":"2014-09-12T08:45:42","guid":{"rendered":"https:\/\/armonia-zoi.gr\/?p=770"},"modified":"2014-09-12T11:45:42","modified_gmt":"2014-09-12T08:45:42","slug":"%ce%b1%cf%80%cf%8c-%cf%84%ce%b1-%cf%80%cf%81%cf%89%cf%84%cf%8c%cf%84%cf%85%cf%80%ce%b1-%cf%83%cf%84%ce%b1-%ce%b3%ce%b5%ce%bd%cf%8c%cf%83%ce%b7%ce%bc%ce%b1-%cf%80%ce%ac%ce%bd%cf%84%ce%b1-%ce%bc%ce%b9","status":"publish","type":"post","link":"https:\/\/armonia-zoi.gr\/%ce%b1%cf%80%cf%8c-%cf%84%ce%b1-%cf%80%cf%81%cf%89%cf%84%cf%8c%cf%84%cf%85%cf%80%ce%b1-%cf%83%cf%84%ce%b1-%ce%b3%ce%b5%ce%bd%cf%8c%cf%83%ce%b7%ce%bc%ce%b1-%cf%80%ce%ac%ce%bd%cf%84%ce%b1-%ce%bc%ce%b9\/","title":{"rendered":"\u0391\u03c0\u03cc \u03c4\u03b1 \u03c0\u03c1\u03c9\u03c4\u03cc\u03c4\u03c5\u03c0\u03b1 \u03c3\u03c4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1. \u03a0\u03ac\u03bd\u03c4\u03b1 \u03bc\u03b9\u03b1 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03b9\u03ba\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae;"},"content":{"rendered":"

\u039a\u03ce\u03c3\u03c4\u03b1 \u03a6\u03b1\u03b9\u03bd\u03ad\u03ba\u03bf\u03c5, \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03cc\u03b3\u03bf\u03c5<\/p>\n

\u03c4. \u0394\u03b9\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae \u03c4\u03bc\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u039c\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd
\n\u0393.\u039d.\u0391 \u00ab \u039a\u03bf\u03c1\u03b3\u03b9\u03b1\u03bb\u03ad\u03bd\u03b5\u03b9\u03bf-\u039c\u03c0\u03b5\u03bd\u03ac\u03ba\u03b5\u03b9\u03bf \u0395\u0395\u03a3\u00bb<\/p>\n

 <\/p>\n

\u0388\u03bd\u03b1 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c3\u03ba\u03b5\u03cd\u03b1\u03c3\u03bc\u03b1, \u03c0\u03ad\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03b7 \u03b7 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03ad\u03c7\u03b5\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03bd\u03cc\u03c3\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9, \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc, \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc, \u03b1\u03c3\u03c6\u03b1\u03bb\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03cc\u03c3\u03bf \u03c4\u03bf \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03bd \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2 \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03c3\u03ba\u03b5\u03c5\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03af\u03b4\u03b9\u03b1\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bf\u03c5\u03c3\u03af\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03b3\u03bf\u03c1\u03ac.<\/p>\n

\u0397 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03b3\u03b5\u03bd\u03bf\u03c3\u03ae\u03bc\u03c9\u03bd \u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03bc\u03b5 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03c0\u03c1\u03c9\u03c4\u03cc\u03c4\u03c5\u03c0\u03bf \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03bf\u03c5\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03af\u03b4\u03b9\u03b5\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2, \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03bc\u03b9\u03b1 \u03ba\u03bf\u03b9\u03bd\u03ae \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c0\u03c1\u03c9\u03c4\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03bf\u03c3\u03ae\u03bc\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae. \u0395\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c0\u03ce\u03c2 \u03b5\u03cd\u03bb\u03bf\u03b3\u03bf \u03c4\u03bf \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c0\u03cc\u03c3\u03bf\u03bd, \u03c0\u03ad\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc \u03c0\u03bb\u03b5\u03bf\u03bd\u03ad\u03ba\u03c4\u03b7\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2, \u03ad\u03bd\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03bf \u03ba\u03b1\u03c4\u03ad\u03c7\u03b5\u03b9 \u03c4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03c0\u03c1\u03c9\u03c4\u03cc\u03c4\u03c5\u03c0\u03bf \u03c3\u03ba\u03b5\u03cd\u03b1\u03c3\u03bc\u03b1.<\/p>\n

\u0397 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03b5\u03bd\u03cc\u03c2 \u03b3\u03b5\u03bd\u03bf\u03c3\u03ae\u03bc\u03bf\u03c5 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf \u03c0\u03c1\u03c9\u03c4\u03cc\u03c4\u03c5\u03c0\u03bf \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03b1\u03c3\u03b8\u03b5\u03af \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2.<\/p>\n

1.\u0391\u03c0\u03cc \u03c4\u03b7 \u03c3\u03cd\u03c3\u03c4\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03c6\u03c5\u03c3\u03b9\u03ba\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b5\u03c7\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bf\u03c5\u03c3\u03af\u03b1\u03c2 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7 \u03c0\u03c1\u03c9\u03c4\u03cc\u03c4\u03c5\u03c0\u03b7.<\/p>\n

2. \u0391\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03c6\u03bf\u03c1\u03ad\u03b1 \u03c3\u03b5 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03bf\u03c5\u03c3\u03af\u03b1.<\/p>\n

3. \u0391\u03c0\u03cc \u03c4\u03bf \u03bc\u03ad\u03b3\u03b5\u03b8\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c7\u03ae\u03bc\u03b1 \u03c4\u03c9\u03bd \u03b4\u03b9\u03c3\u03ba\u03af\u03c9\u03bd \u03cc\u03c4\u03b1\u03bd, \u03c9\u03c2 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2, \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1.<\/p>\n

4.\u0391\u03c0\u03cc \u03c4\u03b7 \u03c4\u03b1\u03c7\u03cd\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bf\u03c5\u03c3\u03af\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c6\u03bf\u03c1\u03ad\u03b1 (\u03b4\u03b9\u03c3\u03ba\u03af\u03bf, \u03ba\u03ac\u03c8\u03bf\u03c5\u03bb\u03b1) \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03bb\u03c5\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c1\u03c1\u03bf\u03c6\u03b7\u03b8\u03b5\u03af.<\/p>\n

5. \u0391\u03c0\u03cc \u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c3\u03c9\u03bb\u03ae\u03bd\u03b1.<\/p>\n

\u038c\u03bb\u03b1 \u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03bf\u03c5\u03bd \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c4\u03b7 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b2\u03b9\u03bf\u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bd\u03cc\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03b1\u03bb\u03bb\u03ac \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03bf\u03b2\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03c9\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03ce\u03bd.<\/p>\n

\u03a3\u03cd\u03c3\u03c4\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c6\u03c5\u03c3\u03b9\u03ba\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2<\/strong><\/p>\n

\u039f\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03b1\u03c5\u03c4\u03bf\u03af \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b1\u03b9\u03c4\u03af\u03b1 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b5\u03bd\u03cc\u03c2 \u03b3\u03b5\u03bd\u03bf\u03c3\u03ae\u03bc\u03bf\u03c5 \u03b5\u03c6\u2019\u03cc\u03c3\u03bf\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03cd\u03ba\u03bf\u03bb\u03bf \u03bc\u03b5 \u03c3\u03c5\u03bd\u03b7\u03b8\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c7\u03b7\u03bc\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03b8\u03cc\u03b4\u03bf\u03c5\u03c2 \u03bd\u03b1 \u03b5\u03bb\u03b5\u03b3\u03c7\u03b8\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03b8\u03bf\u03cd\u03bd \u03c4\u03c5\u03c7\u03cc\u03bd \u03b1\u03c3\u03c4\u03bf\u03c7\u03af\u03b5\u03c2.
\n\u03a0\u03b5\u03c1\u03b9\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong><\/p>\n

\u0395\u03af\u03bd\u03b1\u03b9 \u03c6\u03c5\u03c3\u03b9\u03ba\u03cc \u03cc\u03c4\u03b9 \u03bf\u03c0\u03bf\u03b9\u03b1\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c3\u03c4\u03b7 \u03c0\u03b5\u03c1\u03b9\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03c6\u03bf\u03c1\u03ad\u03b1 \u03b8\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03bf\u03c5 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1 \u03bc\u03b5 \u03b5\u03c0\u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03bf \u03c4\u03b7\u03bd \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03c4\u03b7\u03c2 \u03b2\u03b9\u03bf\u03b9\u03c3\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03bf \u03c0\u03c1\u03c9\u03c4\u03cc\u03c4\u03c5\u03c0\u03bf.<\/p>\n

\u039c\u03ad\u03b3\u03b5\u03b8\u03bf\u03c2, \u03c3\u03c7\u03ae\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03c4\u03c9\u03bd \u03b4\u03b9\u03c3\u03ba\u03af\u03c9\u03bd<\/strong><\/p>\n

\u03a4\u03bf \u03bc\u03ad\u03b3\u03b5\u03b8\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c3\u03c7\u03ae\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03c6\u03bf\u03c1\u03ad\u03b1 (\u03b4\u03b9\u03c3\u03ba\u03af\u03bf \u03b7 \u03ba\u03ac\u03c8\u03bf\u03c5\u03bb\u03b1) \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03ba\u03b1\u03c4\u03ac\u03c0\u03bf\u03c3\u03b7 \u03c4\u03b7 \u03c4\u03b1\u03c7\u03cd\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bf\u03b9\u03c3\u03bf\u03c6\u03b1\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7\u03c2 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c4\u03bf \u03ac\u03c4\u03bf\u03bc\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b5 \u03c5\u03c0\u03c4\u03af\u03b1 \u03b7 \u03b7\u03bc\u03b9\u03ba\u03b1\u03c4\u03b1\u03ba\u03b5\u03ba\u03bb\u03b9\u03bc\u03bc\u03ad\u03bd\u03b7 \u03b8\u03ad\u03c3\u03b7.<\/p>\n

\u039f\u03b9 Channer et al (1) \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ce\u03bd\u03c4\u03b1\u03c2 \u03bc\u03b9\u03ba\u03c1\u03bf\u03cd, \u03bc\u03ad\u03c3\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf\u03c5 \u03bc\u03b5\u03b3\u03ad\u03b8\u03bf\u03c5\u03c2 \u03b4\u03b9\u03c3\u03ba\u03af\u03b1 \u03b8\u03b5\u03b9\u03b9\u03ba\u03bf\u03cd \u03b2\u03b1\u03c1\u03af\u03bf\u03c5 \u03c4\u03cc\u03c3\u03bf \u03c3\u03b5 \u03c3\u03c4\u03c1\u03bf\u03b3\u03b3\u03c5\u03bb\u03ae \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c9\u03bf\u03b5\u03b9\u03b4\u03ae \u03bc\u03bf\u03c1\u03c6\u03ae \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd, \u03ba\u03b1\u03c4\u03b1\u03b3\u03c1\u03ac\u03c6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03c4\u03b1\u03c7\u03cd\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac\u03c0\u03bf\u03c3\u03b7\u03c2 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03ac, \u03cc\u03c4\u03b9 \u03c3\u03c4\u03b7\u03bd \u03cc\u03c1\u03b8\u03b9\u03b1 \u03b8\u03ad\u03c3\u03b7 \u03b4\u03b5\u03bd \u03c5\u03c6\u03af\u03c3\u03c4\u03b1\u03c4\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b7 \u03c4\u03b1\u03c7\u03cd\u03c4\u03b7\u03c4\u03b1 \u03b4\u03b9\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03bc\u03b9\u03ba\u03c1\u03bf\u03cd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c3\u03b1\u03af\u03bf\u03c5 \u03bc\u03b5\u03b3\u03ad\u03b8\u03bf\u03c5\u03c2 \u03b4\u03b9\u03c3\u03ba\u03af\u03c9\u03bd \u03b1\u03bb\u03bb\u03ac \u03c4\u03b1 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf\u03c5 \u03bc\u03b5\u03b3\u03ad\u03b8\u03bf\u03c5\u03c2 \u03c9\u03bf\u03b5\u03b9\u03b4\u03ae \u03b4\u03b9\u03c3\u03ba\u03af\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03b1\u03c7\u03cd\u03c4\u03b5\u03c1\u03bf \u03c7\u03c1\u03cc\u03bd\u03bf \u03b4\u03b9\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c3\u03c4\u03c1\u03bf\u03b3\u03b3\u03c5\u03bb\u03ac.<\/p>\n

\u039f\u03b9 \u03c4\u03b1\u03c7\u03cd\u03c4\u03b7\u03c4\u03b5\u03c2 \u03b4\u03b9\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03bc\u03b9\u03ba\u03c1\u03bf\u03cd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c3\u03b1\u03af\u03bf\u03c5 \u03bc\u03b5\u03b3\u03ad\u03b8\u03bf\u03c5\u03c2 \u03b4\u03b9\u03c3\u03ba\u03af\u03b1 \u03ae\u03c4\u03b1\u03bd \u03b2\u03c1\u03b1\u03c7\u03cd\u03c4\u03b5\u03c1\u03bf\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c9\u03bf\u03b5\u03b9\u03b4\u03ae \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b1 \u03c3\u03c4\u03c1\u03bf\u03b3\u03b3\u03c5\u03bb\u03ac \u03b4\u03b9\u03c3\u03ba\u03af\u03b1. \u039a\u03b1\u03c4\u03b1\u03ba\u03c1\u03ac\u03c4\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bc\u03b5\u03b3\u03ac\u03bb\u03c9\u03bd \u03c9\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd \u03b4\u03b9\u03c3\u03ba\u03af\u03c9\u03bd \u03c3\u03c4\u03bf\u03bd \u03bf\u03b9\u03c3\u03bf\u03c6\u03ac\u03b3\u03bf \u03ba\u03b1\u03c4\u03b1\u03b3\u03c1\u03ac\u03c6\u03b7\u03ba\u03b5 \u03c3\u03c4\u03bf 20% \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03ba\u03b1\u03c4\u03ac\u03c0\u03bf\u03c3\u03b7 \u03c3\u03b5 \u03bf\u03c1\u03b8\u03af\u03b1 \u03b8\u03ad\u03c3\u03b7 \u03b5\u03bd\u03ce \u03bf\u03c5\u03b4\u03b5\u03bc\u03af\u03b1 \u03ba\u03b1\u03c4\u03b1\u03ba\u03c1\u03ac\u03c4\u03b7\u03c3\u03b7 \u03b4\u03b9\u03c3\u03ba\u03af\u03bf\u03c5 \u03bc\u03b5\u03c3\u03b1\u03af\u03bf\u03c5 \u03bc\u03b5\u03b3\u03b5\u03b8\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5.<\/p>\n

\u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1 \u03c3\u03c4\u03b7\u03bd \u03cd\u03c0\u03c4\u03b9\u03b1 \u03b8\u03ad\u03c3\u03b7 \u03bf\u03c5\u03b4\u03b5\u03bc\u03af\u03b1 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03b7\u03bd \u03bf\u03b9\u03c3\u03bf\u03c6\u03b1\u03b3\u03b9\u03ba\u03ae \u03b4\u03b9\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf \u03bc\u03ad\u03b3\u03b5\u03b8\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c3\u03c7\u03ae\u03bc\u03b1 \u03c4\u03c9\u03bd \u03b4\u03b9\u03c3\u03ba\u03af\u03c9\u03bd. \u039a\u03b1\u03c4\u03b1\u03ba\u03c1\u03ac\u03c4\u03b7\u03c3\u03b7 \u03cc\u03bc\u03c9\u03c2 \u03c4\u03c9\u03bd \u03b4\u03b9\u03c3\u03ba\u03af\u03c9\u03bd \u03c3\u03c4\u03bf\u03bd \u03bf\u03b9\u03c3\u03bf\u03c6\u03ac\u03b3\u03bf \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 \u03c0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc \u03c4\u03bf 60% \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03bb\u03ae\u03c8\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c4\u03ce\u03c4\u03b5\u03c1\u03bf \u03bf\u03b9\u03c3\u03bf\u03c6\u03ac\u03b3\u03bf \u03c0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03ba\u03b1\u03c4\u03ce\u03c4\u03b5\u03c1\u03bf \u03bf\u03b9\u03c3\u03bf\u03c6\u03b1\u03b3\u03b9\u03ba\u03cc \u03c3\u03c6\u03b9\u03b3\u03ba\u03c4\u03ae\u03c1\u03b1. \u03a3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf \u03c3\u03c7\u03ae\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bc\u03ad\u03b3\u03b5\u03b8\u03bf\u03c2 \u03c4\u03c9\u03bd \u03b4\u03b9\u03c3\u03ba\u03af\u03c9\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03c4\u03b1\u03c7\u03cd\u03c4\u03b7\u03c4\u03b1 \u03bf\u03b9\u03c3\u03bf\u03c6\u03b1\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03cc\u03c1\u03b8\u03b9\u03b1 \u03b8\u03ad\u03c3\u03b7 \u03b5\u03bd\u03ce \u03c3\u03c4\u03b7\u03bd \u03cd\u03c0\u03c4\u03b9\u03b1 \u03b4\u03b5\u03bd \u03c5\u03c6\u03af\u03c3\u03c4\u03b1\u03c4\u03b1\u03b9 \u03bc\u03b5\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03b1\u03bb\u03bb\u03ac \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03ba\u03b1\u03c4\u03b1\u03ba\u03c1\u03ac\u03c4\u03b7\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c4\u03ce\u03c4\u03b5\u03c1\u03bf \u03bf\u03b9\u03c3\u03bf\u03c6\u03ac\u03b3\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc \u03b3\u03b9\u03b1\u2019 \u03b1\u03c5\u03c4\u03cc \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b1 \u03b4\u03b9\u03c3\u03ba\u03af\u03b1 \u03c3\u03b5 \u03cc\u03c1\u03b8\u03b9\u03b1 \u03b8\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7 \u03bb\u03ae\u03c8\u03b7 \u03c5\u03b3\u03c1\u03ce\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03b5\u03c5\u03ba\u03cc\u03bb\u03c5\u03bd\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac\u03c0\u03bf\u03c3\u03b7\u03c2.<\/p>\n

\u03a0\u03ad\u03c1\u03b1 \u03cc\u03bc\u03c9\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c7\u03ae\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bc\u03ad\u03b3\u03b5\u03b8\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b5\u03af\u03b4\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b4\u03b9\u03c3\u03ba\u03af\u03c9\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03c4\u03b1\u03c7\u03cd\u03c4\u03b7\u03c4\u03b1 \u03bf\u03b9\u03c3\u03bf\u03c6\u03b1\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7\u03c2. \u039f\u03b9 Perkins et al (2) \u03c7\u03bf\u03c1\u03b7\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03bd\u03b1\u03c4\u03c1\u03b9\u03bf\u03cd\u03c7\u03bf \u03c1\u03b9\u03c3\u03b5\u03bd\u03b4\u03c1\u03bf\u03bd\u03ac\u03c4\u03b7, \u03c5\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03bc\u03bf\u03c1\u03c6\u03ae \u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03ac\u03c8\u03bf\u03c5\u03bb\u03b1\u03c2 \u03bc\u03b5 \u03b6\u03b5\u03bb\u03b1\u03c4\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03bc\u03af\u03b1 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03b4\u03b9\u03c3\u03ba\u03af\u03c9\u03bd \u03bc\u03b5 \u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03c5\u03bc\u03b5\u03bd\u03af\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03af\u03bd\u03b7\u03c2, \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd, \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03ba\u03b1\u03c4\u03ac\u03c0\u03bf\u03c3\u03b7 \u03bc\u03b5
\n\u03b3-camera \u03b5\u03bd\u03ce \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03ae\u03c4\u03b1\u03bd \u03c3\u03b5 \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b8\u03ad\u03c3\u03b7, \u03cc\u03c4\u03b9 \u03b7 \u03bf\u03b9\u03c3\u03bf\u03c6\u03b1\u03b3\u03b9\u03ba\u03ae \u03b4\u03b9\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7 \u03ae\u03c4\u03b1\u03bd \u03c4\u03b1\u03c7\u03cd\u03c4\u03b5\u03c1\u03b7 (3,3 sec \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 23,8 sec) \u03bc\u03b5 \u03c4\u03b1 \u03b4\u03b9\u03c3\u03ba\u03af\u03b1 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03af\u03bd\u03b7\u03c2 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ac \u03bc\u03b5 \u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03b6\u03b5\u03bb\u03b1\u03c4\u03af\u03bd\u03b7\u03c2.<\/p>\n

\u03a4\u03b1\u03c7\u03cd\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03bb\u03c5\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong><\/p>\n

\u0397 \u03c4\u03b1\u03c7\u03cd\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b4\u03b9\u03c3\u03ba\u03af\u03b1 \u03b7 \u03ba\u03ac\u03c8\u03bf\u03c5\u03bb\u03b5\u03c2 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c5\u03c7\u03cc\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03bb\u03c5\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bf\u03c5\u03c3\u03af\u03b1\u03c2 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7 \u03c0\u03c1\u03c9\u03c4\u03cc\u03c4\u03c5\u03c0\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03c4\u03b1\u03c7\u03cd\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7\u03c2, \u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c3\u03c9\u03bb\u03ae\u03bd\u03b1 \u03b7 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b2\u03c1\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b2\u03bb\u03b5\u03bd\u03bd\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5 \u03c3\u03ba\u03b5\u03c5\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03b2\u03c1\u03c9\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03cc\u03c0\u03c9\u03c2 \u03c4\u03b1 \u03b4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bd\u03b9\u03ba\u03ac.(3,4).<\/p>\n

\u0397 \u03c4\u03b1\u03c7\u03cd\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c6\u03bf\u03c1\u03ad\u03b1 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03bb\u03c5\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03bb\u03b5\u03b3\u03c7\u03b8\u03bf\u03cd\u03bd \u03bc\u03b5 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03af\u03b5\u03c2 in vitro (3) \u03ba\u03b1\u03b9 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bc\u03c6\u03c9\u03bd\u03bf\u03c5\u03bd \u03bc\u03b5 \u03c4\u03b1 \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b8\u03ad\u03c3\u03b5\u03b9 \u03bf\u03b9 \u03b4\u03b9\u03b5\u03b8\u03bd\u03b5\u03af\u03c2 \u03b5\u03bb\u03b5\u03b3\u03ba\u03c4\u03b9\u03ba\u03bf\u03af \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af (USP30) \u03ba\u03b1\u03b9 \u03c0\u03bf\u03c5 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c4\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c3\u03ba\u03b5\u03cd\u03b1\u03c3\u03bc\u03b1.<\/p>\n

\u03a3\u03b7\u03bc\u03b5\u03af\u03bf \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7\u03c2.<\/strong><\/p>\n

\u0397 \u03c4\u03b1\u03c7\u03cd\u03c4\u03b7\u03c4\u03b1 \u03bf\u03b9\u03c3\u03bf\u03c6\u03b1\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7\u03c2, \u03b7 \u03b8\u03ad\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03bb\u03ae\u03c8\u03b7 \u03c4\u03c9\u03bd \u03b4\u03b9\u03c3\u03ba\u03af\u03c9\u03bd, \u03b7 \u03b4\u03b9\u03b1\u03bb\u03c5\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03c4\u03b1\u03c7\u03cd\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c6\u03bf\u03c1\u03ad\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03b3\u03ba\u03cc\u03bb\u03bb\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b4\u03b9\u03c3\u03ba\u03af\u03c9\u03bd \u03c3\u03c4\u03bf\u03bd \u03bf\u03b9\u03c3\u03bf\u03c6\u03b1\u03b3\u03b9\u03ba\u03cc \u03b2\u03bb\u03b5\u03bd\u03bd\u03bf\u03b3\u03cc\u03bd\u03bf \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 (5) \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03bf\u03c5\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c0\u03b9\u03bf \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae, \u03cc\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03b1\u03bb\u03bb\u03ac \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c4\u03b7 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae \u03b2\u03bb\u03b1\u03c0\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03bf \u03b2\u03bb\u03b5\u03bd\u03bd\u03bf\u03b3\u03cc\u03bd\u03bf, \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03ba\u03c1\u03ac\u03c4\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bf\u03c5\u03c3\u03af\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03ba\u03b1\u03c4\u03ce\u03c4\u03b5\u03c1\u03bf \u03c4\u03bc\u03ae\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03bf\u03b9\u03c3\u03bf\u03c6\u03ac\u03b3\u03bf\u03c5.<\/p>\n

\u039f\u03bb\u03bf\u03b9 \u03bf\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03bd \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03ac\u03bb\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1, \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2-\u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03b5\u03bd\u03bf\u03c3\u03ae\u03bc\u03bf\u03c5 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf \u03c0\u03c1\u03c9\u03c4\u03cc\u03c4\u03c5\u03c0\u03bf \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c3\u03ba\u03b5\u03cd\u03b1\u03c3\u03bc\u03b1.<\/p>\n

\u0395\u03af\u03bd\u03b1\u03b9 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c0\u03c1\u03c9\u03c4\u03bf\u03c4\u03cd\u03c0\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03bf\u03c3\u03ae\u03bc\u03c9\u03bd \u03c3\u03c4\u03b7 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03c4\u03c9\u03bd \u03b4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bd\u03b9\u03ba\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03c3\u03c4\u03b5\u03bf\u03c0\u03cc\u03c1\u03c9\u03c3\u03b7\u03c2.<\/p>\n

\u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 in vitro \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03cc\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03ac\u03bb\u03c5\u03c3\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5 Fosamax \u03ba\u03b1\u03b9 \u03b5\u03bd\u03bd\u03ad\u03b1 \u03b3\u03b5\u03bd\u03bf\u03c3\u03ae\u03bc\u03c9\u03bd \u03c4\u03bf\u03c5 \u0391\u03bb\u03b5\u03bd\u03b4\u03c1\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd \u03bf\u03be\u03ad\u03bf\u03c2 (6) \u03c9\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03bf\u03b9\u03c3\u03bf\u03c6\u03b1\u03b3\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03bb\u03ba\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03c3\u03ba\u03cd\u03bb\u03bf\u03c5\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5\u03c2 \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u0391\u03bb\u03b5\u03bd\u03b4\u03c1\u03bf\u03bd\u03ac\u03c4\u03b7\u03c2 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf \u03c0\u03c1\u03c9\u03c4\u03cc\u03c4\u03c5\u03c0\u03bf Fosamax.(7).<\/p>\n

\u0394\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03c9\u03c2 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03c9\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03ce\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af \u03c3\u03b5 \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c0\u03c1\u03c9\u03c4\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03bf\u03c3\u03ae\u03bc\u03bf\u03c5 \u0391\u03bb\u03b5\u03bd\u03b4\u03c1\u03bf\u03bd\u03ac\u03c4\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03c9\u03c4\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5 \u03c1\u03b9\u03c3\u03b5\u03bd\u03b4\u03c1\u03bf\u03bd\u03ac\u03c4\u03b7\u03c2
\n(70 mg \u03ba\u03b1\u03b9 35mg \u03b5\u03b2\u03b4\u03bf\u03bc\u03b1\u03b4\u03b9\u03b1\u03af\u03c9\u03c2 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1), \u03bf\u03c0\u03bf\u03c5 \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03c0\u03c1\u03c9\u03c4\u03cc\u03c4\u03c5\u03c0\u03b1 \u03c4\u03bf \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03bf \u03ae\u03c4\u03b1\u03bd \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c9\u03c2 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c5\u03ba\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03c4\u03b7 \u03c3\u03c0\u03bf\u03bd\u03b4\u03c5\u03bb\u03b9\u03ba\u03ae \u03c3\u03c4\u03ae\u03bb\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b9\u03c3\u03c7\u03af\u03bf \u03b5\u03bd\u03ce \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b5 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03c9\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03ce\u03bd (8) \u03b5\u03bd\u03ce \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c0\u03c1\u03c9\u03c4\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03bf\u03c3\u03ae\u03bc\u03bf\u03c5 \u03b1\u03bb\u03b5\u03bd\u03b4\u03c1\u03bf\u03bd\u03ac\u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03c9\u03c4\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5 \u03bc\u03b5 \u03c4\u03bf \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03bf. (9).<\/p>\n

\u0394\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03c9\u03c2 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7 \u03c4\u03b7 \u03b2\u03b9\u03bf\u03b9\u03c3\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c0\u03c1\u03c9\u03c4\u03bf\u03c4\u03cd\u03c0\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03bf\u03c3\u03ae\u03bc\u03c9\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af \u03c3\u03c4\u03b7 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03c4\u03c9\u03bd \u03c8\u03c5\u03c7\u03bf\u03c4\u03c1\u03cc\u03c0\u03c9\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd (10,11,12) \u03b5\u03bd\u03ce \u03c3\u03c4\u03b7 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03b9\u03b1 \u03c4\u03c9\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03bc\u03b5 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c3\u03c4\u03bf \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1, \u03c0\u03b1\u03c1\u0384\u03cc\u03bb\u03bf \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03b5\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c9\u03c4\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03bf\u03c4\u03cd\u03c0\u03c9\u03bd, \u03b5\u03bd\u03b1\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 \u03ac\u03c1\u03b8\u03c1\u03c9\u03bd \u03c3\u03c5\u03bd\u03b7\u03b3\u03bf\u03c1\u03b5\u03af \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03bc\u03b5 \u03c4\u03b1 \u03c0\u03c1\u03c9\u03c4\u03cc\u03c4\u03c5\u03c0\u03b1 \u03c3\u03ba\u03b5\u03c5\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1.(13)<\/p>\n

\u0397 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 \u03c0\u03b5\u03c1\u03b9\u03ba\u03bf\u03c0\u03ad\u03c2 \u03c3\u03c4\u03bf \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b1\u03c0\u03ac\u03bd\u03b7\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03c4\u03b1\u03b3\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03c3\u03b7\u03c2 \u03b3\u03b5\u03bd\u03bf\u03c3\u03ae\u03bc\u03c9\u03bd \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03bb\u03ae\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c4\u03ad\u03bd\u03c4\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03bf\u03c4\u03cd\u03c0\u03c9\u03bd. \u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2 \u03b4\u03b9\u03cc\u03c4\u03b9 \u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03b2\u03b1\u03c1\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b1 \u03ad\u03be\u03bf\u03b4\u03b1 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2. \u0397 \u03bc\u03cc\u03bd\u03b7 \u03c0\u03c1\u03bf\u03c5\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03ba\u03c4\u03b7\u03c3\u03b7 \u03ac\u03b4\u03b5\u03b9\u03b1\u03c2 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03c9\u03bd \u03b2\u03b9\u03bf\u03b9\u03c3\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1\u03c2, \u03b7 \u03c4\u03b1\u03cd\u03c4\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03c4\u03bf\u03c5\u03c2 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ac \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03bf\u03c4\u03cd\u03c0\u03c9\u03bd, \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bc\u03c9\u03c2 \u03bd\u03b1 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c5\u03c0\u2019 \u03cc\u03c8\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03b5\u03b8\u03bd\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 \u03b1\u03b4\u03b5\u03b9\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b3\u03b5\u03bd\u03bf\u03c3\u03ae\u03bc\u03c9\u03bd \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03c0\u03c1\u03c9\u03c4\u03cc\u03c4\u03c5\u03c0\u03b1.(14)<\/p>\n

\u0391\u03ba\u03cc\u03bc\u03b7 \u03cc\u03bc\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b8\u03ad\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b1 \u03c0\u03c1\u03c9\u03c4\u03cc\u03c4\u03c5\u03c0\u03b1 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bc\u03c6\u03b9\u03c3\u03b2\u03b7\u03c4\u03ae\u03c3\u03b9\u03bc\u03bf \u03cc\u03c0\u03c9\u03c2 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ad\u03c1\u03b5\u03c5\u03bd\u03b5\u03c2 \u03b1\u03b3\u03bf\u03c1\u03ac\u03c2 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03c7\u03ce\u03c1\u03b5\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b7 \u0395\u03bb\u03bb\u03ac\u03b4\u03b1 \u03bc\u03b5 \u03b1\u03bd\u03b5\u03c0\u03b1\u03c1\u03ba\u03b5\u03af\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b1\u03c0\u03ac\u03bd\u03b7\u03c2 (15).<\/p>\n

\u0394\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b1\u03bc\u03c6\u03b9\u03b2\u03bf\u03bb\u03af\u03b1 \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c0\u03c1\u03af\u03bd \u03c4\u03bf\u03c5\u03c2 \u03c7\u03bf\u03c1\u03b7\u03b3\u03b7\u03b8\u03b5\u03af \u03ac\u03b4\u03b5\u03b9\u03b1 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1\u03c2 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c5\u03c0\u03bf\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c5\u03c3\u03c4\u03b7\u03c1\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c9\u03c2 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03ac, \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03b5\u03bd\u03ce \u03b7 \u03c4\u03b9\u03bc\u03ae \u03c4\u03bf\u03c5\u03c2 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c6\u03ad\u03c1\u03b5\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b1\u03c0\u03ac\u03bd\u03b7\u03c2 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03bd\u03c4\u03b1\u03b3\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03bf\u03c5 \u03c0\u03c1\u03c9\u03c4\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5.
\n\u0392\u0399\u0392\u039b\u0399\u039f\u0393\u03a1\u0391\u03a6\u0399\u0391<\/p>\n

1. Channer K.S et al. The effect of size and shape of tablets on their esophageal transit. J Clin Pharmacol 1985; 141-146<\/p>\n

2. Perkins A.C et al. Esophageal transit of risendronate cellulose-coated tablet and gelatine capsule formulations. Int J Pharmaceutics. 1999;186, 169-175<\/p>\n

3.Dansereau R J et al. In vitro disintegration and dissolution studies of once-weekly copies of alendronate sodium tablets (70 mg) and in vivo implications.
\nCur Med Res opin 2008; 24, 1137-1145<\/p>\n

4. Perkins A C et al. Esophageal transit and in vivo disintegration of branded risendronate sodium tablets and two generic formulations of alendronic acid tablets: A single- center,single-blind,six-period crossover study in healthy female subjects. Clin Therapeutics; 2008, 30, 834-844<\/p>\n

5.Shakweh M et al. Comparative in vitro study of esophageal adhesiveness of different commercial formulations containing alendronate. Eur J Pharmaceutical Sciences. 2007;31, 262-270.<\/p>\n

6. Epstein S et al. Disintegration \/dissolution profiles of copies of Fosamax (Alendronate) Curr Med Res Opin.2003;19:781-789<\/p>\n

7. Epstein s et al. Disintegration and esophageal irritation profiles of alendronate formulations: implications for clinical safety and efficacy. J Appl Res 2005;5,253-265.<\/p>\n

8. Ringe J D.et al. Differences in safety and efficacy of generic and original branded once weekly biphosphonates. 2008. ASBMR annual meeting. Abstract book.<\/p>\n

9. Grima D et al. Treatment discontinuation due to gastrointestinal adverse events and decreased bone mineral density in patients switched from branded alendronate to generic aledronate. 2008; ASBMR annual meeting. Abstract book.<\/p>\n

10. Borgheini G. The bioequivalence and therapeutic efficacy of generic versus brand-name psychoactive drugs.2003; Clin Ther. 25: 1578-1592<\/p>\n

11.Mofsen R et al. Case reports of the re-emergence of psychotic symptoms after conversion from brand \u2013name clozapine to a generic formulation. 2001. Clin Ther. 23; 17201731.<\/p>\n

12.Burkhardt et al. Lower phenytoin serum levels in persons switched from brand to generic Phenytoin. 2004. Neurology;63, 1494-1496.<\/p>\n

13.Kesselheim As et al. Clinical equivalence of generic and brand-name drugs used in cardiovascular disease: a systematic review and meta-analysis.
\n2008, JAMA: 300, 2514-2526<\/p>\n

14.Solanki T. Switching to generics: always a cost- effective option? Presciber, August 2008.<\/p>\n

15. \u039d\u03c4\u03b1\u03bd\u03b9 \u0392\u03ad\u03c1\u03b3\u03bf\u03c5. \u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1: \u0397 \u03c3\u03c5\u03bd\u03c4\u03b1\u03b3\u03ae \u03c4\u03b7\u03c2 \u03ba\u03b5\u03c1\u03b4\u03bf\u03c3\u03ba\u03bf\u03c0\u03af\u03b1\u03c2. \u0395\u03bb\u03b5\u03c5\u03b8\u03b5\u03c1\u03bf\u03c4\u03c5\u03c0\u03af\u03b1. 30 \u0399\u03b1\u03bd\u03bf\u03c5\u03b1\u03c1\u03af\u03bf\u03c5 2010. 40-41<\/p>\n","protected":false},"excerpt":{"rendered":"

\u0388\u03bd\u03b1 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c3\u03ba\u03b5\u03cd\u03b1\u03c3\u03bc\u03b1, \u03c0\u03ad\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03b7 \u03b7 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03ad\u03c7\u03b5\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03bd\u03cc\u03c3\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9, \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc, \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc, \u03b1\u03c3\u03c6\u03b1\u03bb\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03cc\u03c3\u03bf \u03c4\u03bf \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03bd \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2 \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03c3\u03ba\u03b5\u03c5\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03af\u03b4\u03b9\u03b1\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bf\u03c5\u03c3\u03af\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03b3\u03bf\u03c1\u03ac.<\/p>\n

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