{"id":919,"date":"2015-06-22T11:06:37","date_gmt":"2015-06-22T08:06:37","guid":{"rendered":"https:\/\/armonia-zoi.gr\/?p=919"},"modified":"2015-07-10T10:24:15","modified_gmt":"2015-07-10T07:24:15","slug":"%ce%b4%ce%b9%ce%b1%cf%84%cf%81%ce%bf%cf%86%ce%bf%ce%b3%ce%b5%ce%bd%ce%b5%cf%84%ce%b9%ce%ba%ce%ae-%ce%ba%ce%b1%ce%b9-%ce%b4%ce%b9%ce%b1%cf%84%cf%81%ce%bf%cf%86%ce%bf%ce%b3%ce%b5%ce%bd%cf%89%ce%bc%ce%b9","status":"publish","type":"post","link":"https:\/\/armonia-zoi.gr\/%ce%b4%ce%b9%ce%b1%cf%84%cf%81%ce%bf%cf%86%ce%bf%ce%b3%ce%b5%ce%bd%ce%b5%cf%84%ce%b9%ce%ba%ce%ae-%ce%ba%ce%b1%ce%b9-%ce%b4%ce%b9%ce%b1%cf%84%cf%81%ce%bf%cf%86%ce%bf%ce%b3%ce%b5%ce%bd%cf%89%ce%bc%ce%b9\/","title":{"rendered":"\u0394\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b3\u03b5\u03bd\u03c9\u03bc\u03b9\u03ba\u03ae \u03c4\u03b7\u03c2 \u03a0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1\u03c2"},"content":{"rendered":"<p class=\"western\" lang=\"el-GR\"><b>\u03a7\u03ac\u03c1\u03b7\u03c2 \u039a\u03b1\u03bd\u03b4\u03b7\u03bb\u03ce\u03c1\u03bf\u03c2,\u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2,\u0394\u03b9\u03b1\u03b2\u03b7\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2<br \/>\n<\/b><b style=\"letter-spacing: 0.05em; line-height: 1.6875;\">\u0394\u03b9\u03b4\u03ac\u03ba\u03c4\u03c9\u03c1. \u03a4. \u03b5\u03c0\u03b9\u03bc\u03b5\u03bb\u03b7\u03c4\u03ae\u03c2 \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03af\u03bf\u03c5 Nancy<br \/>\n<\/b><b style=\"letter-spacing: 0.05em; line-height: 1.6875;\">harican@otenet.gr<\/b><\/p>\n<p class=\"western\" lang=\"el-GR\">\u0393\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03cd\u03bb\u03b7\u03c0\u03c4\u03bf \u03c4\u03bf \u03c0\u03b1\u03c1\u03cc\u03bd \u03b8\u03ad\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03bf \u03c0\u03b5\u03b4\u03af\u03bf \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1\u03c2, \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b3\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2, \u03b3\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b3\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1\u03c2.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0395\u03c0\u03b5\u03b9\u03b4\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03bd \u03bc\u03b5\u03c1\u03b9\u03ba\u03bf\u03af \u03cc\u03c1\u03bf\u03b9 \u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03bb\u03b7\u03c3\u03bc\u03bf\u03bd\u03b7\u03b8\u03b5\u03af \u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ac \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03b9, \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd \u03ba\u03cd\u03c1\u03b9\u03bf \u03ba\u03bf\u03c1\u03bc\u03cc \u03c4\u03bf\u03c5 \u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b4\u03c5\u03c3\u03bd\u03cc\u03b7\u03c4\u03bf, \u03c0\u03b1\u03c1\u03b1\u03c4\u03af\u03b8\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b7 \u03b5\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03b9\u03ba\u03ae \u03b5\u03c0\u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7.<\/p>\n<p class=\"western\" lang=\"el-GR\"><b>1. \u0392\u03b1\u03c3\u03b9\u03ba\u03bf\u03af \u00ab\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03af\u00bb \u03cc\u03c1\u03bf\u03b9<\/b><\/p>\n<p class=\"western\" lang=\"el-GR\"><u>\u0393\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bc\u03b1<\/u> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03c4\u03bf\u03c5 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03c5\u03bb\u03b9\u03ba\u03bf\u03cd (<span lang=\"en-US\">DN<\/span>\u0391) \u03c0\u03bf\u03c5 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0391\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03c4\u03bf\u03cd\u03bd \u03ad\u03bd\u03b1 \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03b9\u03ba\u03cc \u03bf\u03be\u03cd \u03bc\u03b5 \u03bc\u03b9\u03b1 \u03b4\u03b5\u03c3\u03bf\u03be\u03c5\u03c1\u03b9\u03b2\u03cc\u03b6\u03b7 (\u03c0\u03b5\u03bd\u03c4\u03cc\u03b6\u03b7 = \u03c3\u03ac\u03ba\u03c7\u03b1\u03c1\u03bf \u03bc\u03b5 5 \u03ac\u03bd\u03b8\u03c1\u03b1\u03ba\u03b5\u03c2) \u03ba\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b1\u03b6\u03c9\u03c4\u03bf\u03cd\u03c7\u03bf\u03c2 \u03b2\u03ac\u03c3\u03b7 \u03c0\u03bf\u03c5\u03c1\u03af\u03bd\u03b7 (\u03b8\u03c5\u03bc\u03af\u03bd\u03b7, \u03ba\u03c5\u03c4\u03bf\u03c3\u03af\u03bd\u03b7) \u03ae \u03c0\u03c5\u03c1\u03b9\u03bc\u03b9\u03b4\u03af\u03bd\u03b7 (\u03b1\u03b4\u03b5\u03bd\u03af\u03bd\u03b7, \u03b3\u03bf\u03c5\u03b1\u03bd\u03af\u03bd\u03b7) \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03b5\u03b9 \u03ad\u03bd\u03b1 <u>\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03bf<\/u>.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a4\u03bf <span lang=\"en-US\">DN<\/span>\u0391 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b9\u03c0\u03bb\u03ae \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b1\u03bd\u03c4\u03b9\u03ba\u03c1\u03b9\u03c3\u03c4\u03ad\u03c2 \u03b2\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03b7 \u03b3\u03bf\u03c5\u03b1\u03bd\u03af\u03bd\u03b7 \u03bc\u03b5 \u03ba\u03c5\u03c4\u03bf\u03c3\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03b8\u03c5\u03bc\u03af\u03bd\u03b7 \u03bc\u03b5 \u03b1\u03b4\u03b5\u03bd\u03af\u03bd\u03b7. \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03b5\u03c0\u03af \u03c4\u03b7\u03c2 \u03b9\u03b4\u03af\u03b1\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1\u03c2, \u03b7 \u03b3\u03bf\u03c5\u03b1\u03bd\u03af\u03bd\u03b7 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ac\u03bc\u03b5\u03c3\u03b7 \u03b3\u03b5\u03b9\u03c4\u03bd\u03af\u03b1\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03bf\u03c3\u03af\u03bd\u03b7. \u03a4\u03b1 <u>\u03b4\u03b9\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03b1 <\/u><span lang=\"en-US\"><u>CpG<\/u><\/span> \u03bb\u03bf\u03b9\u03c0\u03cc\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03c3\u03c4\u03bf <span lang=\"en-US\">DNA<\/span>. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2 \u03cc\u03c0\u03bf\u03c5 \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03b4\u03b9\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03ad\u03c4\u03bf\u03b9\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03cc\u03c1\u03bf \u00ab\u03bd\u03b7\u03c3\u03af\u03b4\u03b9\u03b1 <span lang=\"en-US\">CpG<\/span>\u00bb \u03ba\u03b1\u03b9 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ce\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03b3\u03cd\u03c1\u03c9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ad\u03c2 <span lang=\"en-US\">promoters<\/span>.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a4\u03bf <span lang=\"en-US\">DNA<\/span> \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03c5\u03c0\u03cc \u03bc\u03bf\u03c1\u03c6\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b5\u03bb\u03b9\u03b3\u03bc\u03ad\u03bd\u03b7 \u03c0\u03bf\u03c5 \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03bf\u03c5\u03bc\u03b5 \u03c7\u03c1\u03c9\u03bc\u03cc\u03c3\u03c9\u03bc\u03b1. \u0397 \u03c0\u03b5\u03c1\u03b9\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03bf\u03c5 <span lang=\"en-US\">DNA<\/span> \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b1\u03bd \u03bd\u03ae\u03bc\u03b1 \u03c4\u03c5\u03bb\u03b9\u03b3\u03bc\u03ad\u03bd\u03bf \u03b3\u03cd\u03c1\u03c9 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1 \u03bf\u03ba\u03c4\u03b1\u03bc\u03b5\u03c1\u03ae \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b6\u03b5\u03cd\u03b3\u03b7 \u03c4\u03b5\u03c3\u03c3\u03ac\u03c1\u03c9\u03bd \u03b1\u03bb\u03ba\u03b1\u03bb\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd, \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 <u>\u03b9\u03c3\u03c4\u03cc\u03bd\u03b5\u03c2<\/u> \u03972\u0391, \u03972\u039d, \u03973 \u039a\u0391\u0399 \u03974. \u03a4\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03cc\u03c3\u03c9\u03bc\u03b1.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a4\u03bf <span lang=\"en-US\">DNA<\/span> \u03c5\u03c6\u03af\u03c3\u03c4\u03b1\u03c4\u03b1\u03b9 <u>\u03b1\u03bd\u03c4\u03b9\u03b3\u03c1\u03b1\u03c6\u03ae<\/u> (<span lang=\"en-US\">replication<\/span>) \u03c3\u03c4\u03b7\u03bd \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03b1\u03af\u03c1\u03b5\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b2\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b6\u03cd\u03bc\u03bf\u03c5 <span lang=\"en-US\">DNA<\/span> \u03c0\u03bf\u03bb\u03c5\u03bc\u03b5\u03c1\u03ac\u03c3\u03b7. \u03a5\u03c6\u03af\u03c3\u03c4\u03b1\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 <u>\u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae<\/u> (<span lang=\"en-US\">transcription<\/span>) \u03c3\u03b5 <span lang=\"en-US\">mRNA<\/span> \u03c7\u03ac\u03c1\u03b9\u03c2 \u03c3\u03c4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf <span lang=\"en-US\">RNA<\/span> \u03c0\u03bf\u03bb\u03c5\u03bc\u03b5\u03c1\u03ac\u03c3\u03b7. \u0391\u03c5\u03c4\u03cc \u03c4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03bc\u03b9\u03ba\u03c1\u03ae \u03c4\u03bf\u03c0\u03bf\u03b8\u03b5\u03c3\u03af\u03b1 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2 (<span lang=\"en-US\">binding<\/span> <span lang=\"en-US\">site<\/span>) \u03c3\u03c4\u03bf <span lang=\"en-US\">DNA<\/span> \u03b4\u03af\u03c0\u03bb\u03b1 \u03c3\u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03ac\u03c8\u03b5\u03b9. \u0391\u03c5\u03c4\u03cc \u03c4\u03bf \u03c4\u03bc\u03ae\u03bc\u03b1 \u03c4\u03bf\u03c5 <span lang=\"en-US\">DNA<\/span> \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf <u>\u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae\u03c2<\/u> \u03ae \u03c5\u03c0\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae\u03c2 (<span lang=\"fr-FR\">p<\/span><span lang=\"en-US\">romoter<\/span>).<\/p>\n<p class=\"western\" lang=\"el-GR\"><u>\u0399\u03bd\u03c4\u03c1\u03cc\u03bd\u03b9\u03b1<\/u> (introns) \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c6\u03b1\u03b9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf mRNA \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03c9\u03c2 \u03c3\u03c5\u03b3\u03ba\u03cc\u03bb\u03bb\u03b7\u03c3\u03b7 (splicing). \u039f\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd, \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ad\u03c2 \u03c9\u03c2 <u>\u03b5\u03be\u03cc\u03bd\u03b9\u03b1<\/u> (exons).<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03c4\u03bf <span lang=\"en-US\">mRNA<\/span> \u03ba\u03b9\u03bd\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c1\u03b9\u03b2\u03cc\u03c3\u03c9\u03bc\u03b1, \u03cc\u03c0\u03bf\u03c5 \u03b8\u03b1 \u03bb\u03ac\u03b2\u03b5\u03b9 \u03c7\u03ce\u03c1\u03b1 \u03b7 <u>\u03bc\u03b5\u03c4\u03ac\u03c6\u03c1\u03b1\u03c3\u03b7<\/u> (<span lang=\"en-US\">traduction<\/span>). \u0395\u03ba\u03b5\u03af \u03c0\u03b1\u03af\u03c1\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03ba\u03c5\u03c4\u03ac\u03bb\u03b7 \u03c4\u03bf <span lang=\"en-US\">tRNA<\/span> \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b8\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03c4\u03b1 \u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03c3\u03b5\u03b9\u03c1\u03ac \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03b9\u03bd\u03ce\u03bd. <u>\u039a\u03c9\u03b4\u03b9\u03ba\u03cc\u03bd\u03b9\u03bf<\/u> (<span lang=\"en-US\">codon<\/span>) \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03af\u03b1 \u03c4\u03c1\u03b9\u03ce\u03bd \u03b2\u03ac\u03c3\u03b5\u03c9\u03bd \u03c3\u03c4\u03bf mRNA \u03ba\u03b1\u03b9 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03b3\u03b9\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03cd.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0397 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1 \u03c4\u03bf\u03c5 <span lang=\"en-US\">DNA<\/span> \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c3\u03b5 \u03c4\u03c1\u03b5\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2: 1) \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03c3\u03b5\u03be\u03bf\u03c5\u03b1\u03bb\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03bd\u03b1\u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c7\u03ce\u03c1\u03b1 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03bf\u03bc\u03bf\u03bb\u03cc\u03b3\u03c9\u03bd \u03c7\u03c1\u03c9\u03bc\u03b1\u03c4\u03bf\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03bc\u03b5\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03af\u03c1\u03b5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b4\u03af\u03bd\u03b5\u03b9 \u03b3\u03ad\u03bd\u03bd\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03bd\u03ad\u03bf \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bc\u03b1, 2) \u03bc\u03b5 \u03bc\u03b9\u03ba\u03c1\u03ad\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 (genetic variation<span lang=\"en-US\">s<\/span>) \u03ae, \u03c0\u03bf\u03bb\u03cd \u03c3\u03c0\u03b1\u03bd\u03b9\u03cc\u03c4\u03b5\u03c1\u03b1, 3) \u03bc\u03b5 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2. \u03a4\u03b9\u03c2 \u03bc\u03b9\u03ba\u03c1\u03ad\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2, \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03ad\u03bd\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03bf, \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03bf\u03c5\u03bc\u03b5 \u00ab<u>\u03c3\u03bd\u03b9\u03c0<\/u>\u00bb (<span lang=\"en-US\">SNP<\/span> <span lang=\"en-GB\">single<\/span> <span lang=\"en-GB\">nucleotide<\/span> <span lang=\"en-GB\">polymorphism<\/span> \u03ae <span lang=\"en-US\">SGNP<\/span>).<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0388\u03c4\u03c3\u03b9 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b7 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bc\u03b5 \u03b4\u03cd\u03bf (\u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03cc\u03c7\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03b1\u03c0\u03cc \u03b4\u03cd\u03bf) <u>\u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03bc\u03cc\u03c1\u03c6\u03bf\u03c5\u03c2<\/u> (<span lang=\"en-US\">alleles<\/span>) \u03b3\u03b9\u03b1 \u03bc\u03b9\u03b1 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae \u03b8\u03ad\u03c3\u03b7 (<span lang=\"en-US\">gene<\/span> <span lang=\"en-US\">locus<\/span>). <u>\u0391\u03c0\u03bb\u03cc\u03c4\u03c5\u03c0\u03bf\u03c2<\/u> \u03bb\u03ad\u03b3\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03bc\u03cc\u03c1\u03c6\u03c9\u03bd \u03c0\u03bf\u03c5 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b1\u03b6\u03af.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a3\u03c4\u03b9\u03c2 16 \u039f\u03ba\u03c4\u03c9\u03b2\u03c1\u03af\u03bf\u03c5 2014, \u03b7 \u03b2\u03ac\u03c3\u03b7 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd <span lang=\"en-US\">S<\/span>NP \u03c0\u03b5\u03c1\u03b9\u03b5\u03af\u03c7\u03b5 \u03c0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc \u03b5\u03ba\u03b1\u03c4\u03cc \u03b5\u03ba\u03b1\u03c4\u03bf\u03bc\u03bc\u03cd\u03c1\u03b9\u03b1 (\u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03ba\u03c1\u03af\u03b2\u03b5\u03b9\u03b1 112.736.879) SNPs \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf, \u03ba\u03b1\u03b9 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ac \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03bc\u03c0\u03bb\u03bf\u03c5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0391\u03c5\u03c4\u03cc\u03c2 \u03bf \u03bc\u03bf\u03bd\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03ca\u03b4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03c9\u03bd \u03bc\u03b9\u03ba\u03c1\u03bf\u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ce\u03bd \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03c9\u03bd. \u03a4\u03bf \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bc\u03b1 \u03bc\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03bc\u03bf\u03b9\u03bf \u03ba\u03b1\u03c4\u03ac 99,9%. \u039f\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac (\u03bc\u03ac\u03c4\u03b9\u03b1, \u03bc\u03b1\u03bb\u03b9\u03ac \u03ba\u03bb\u03c0), \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u03c3\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf 0,1%.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u039f\u03b9 \u03c0\u03bb\u03bf\u03c5\u03c3\u03b9\u03cc\u03c4\u03b1\u03c4\u03b7 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03bf\u03b9\u03bd\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c3\u03c7\u03ad\u03c3\u03b7 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03c4\u03b1\u03b9 \u03b3\u03cd\u03c1\u03c9 \u03b1\u03c0\u03cc \u03c4\u03c1\u03b5\u03b9\u03c2 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03bb\u03ad\u03be\u03b5\u03b9\u03c2 \u03ba\u03bb\u03b5\u03b9\u03b4\u03b9\u03ac: \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae, \u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b3\u03b5\u03bd\u03c9\u03bc\u03b9\u03ba\u03ae. \u039f\u03b9 \u03c4\u03c1\u03b5\u03b9\u03c2 \u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03af \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b1\u03c6\u03b5\u03af\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03ad\u03bd\u03bd\u03bf\u03b9\u03b5\u03c2 \u03bb\u03b5\u03c0\u03c4\u03ad\u03c2.<\/p>\n<p class=\"western\" lang=\"el-GR\"><b>2. \u0394\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae (<\/b><span lang=\"fr-FR\"><b>Nutrigenetics<\/b><\/span><b>)<\/b><\/p>\n<p class=\"western\" lang=\"el-GR\">\u0397 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03b5\u03c4\u03ac\u03b5\u03b9 \u03c0\u03ce\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2, \u03bf\u03c6\u03b5\u03b9\u03bb\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03bf (\u03c3\u03bd\u03b9\u03c0\u03c2), \u03b4\u03af\u03bd\u03bf\u03c5\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03af\u03b4\u03b9\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03c2 \u03c4\u03c1\u03bf\u03c6\u03ae\u03c2.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0391\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd \u03bc\u03b5\u03c1\u03b9\u03ba\u03ac \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ac \u03c0\u03b1\u03c1\u03b1\u03b4\u03b5\u03af\u03b3\u03bc\u03b1\u03c4\u03b1 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2.<\/p>\n<p class=\"western\" lang=\"el-GR\"><u>1 \u03a6\u03b1\u03b9\u03bd\u03c5\u03bb\u03ba\u03b5\u03c4\u03bf\u03bd\u03bf\u03c5\u03c1\u03af\u03b1<\/u><\/p>\n<p class=\"western\" lang=\"el-GR\">\u0397 \u03c6\u03b1\u03b9\u03bd\u03c5\u03bb\u03b1\u03bb\u03b1\u03bd\u03af\u03bd\u03b7 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03ad\u03c0\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c4\u03c5\u03c1\u03bf\u03c3\u03af\u03bd\u03b7 \u03c7\u03ac\u03c1\u03b9\u03c2 \u03c3\u03c4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03bb\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c6\u03b1\u03b9\u03bd\u03c5\u03bb\u03b1\u03bb\u03b1\u03bd\u03af\u03bd\u03b7\u03c2 (\u03a1\u0391\u0397). \u03a3\u03c4\u03b7\u03bd \u03c6\u03b1\u03b9\u03bd\u03c5\u03bb\u03ba\u03b5\u03c4\u03bf\u03bd\u03bf\u03c5\u03c1\u03af\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03b1\u03bd\u03c9\u03bc\u03b1\u03bb\u03af\u03b1 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03bf <span lang=\"fr-FR\">x<\/span>\u03c1\u03c9\u03bc\u03cc\u03c3\u03c9\u03bc\u03b1 12<span lang=\"en-US\">q<\/span>24.1 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b6\u03cd\u03bc\u03bf\u03c5 \u03a1\u0391\u0397 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c3\u03c3\u03ce\u03c1\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c6\u03b1\u03b9\u03bd\u03c5\u03bb\u03b1\u03bb\u03b1\u03bd\u03af\u03bd\u03b7\u03c2 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c4\u03bf\u03be\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03b5\u03b3\u03ba\u03ad\u03c6\u03b1\u03bb\u03bf. \u0391\u03bd \u03b7 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03b4\u03b5\u03bd \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 \u03c6\u03b1\u03b9\u03bd\u03c5\u03bb\u03b1\u03bb\u03b1\u03bd\u03af\u03bd\u03b7, \u03b4\u03b5\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<br \/>\n<u>2 \u0394\u03c5\u03c3\u03b1\u03bd\u03b5\u03be\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03bb\u03b1\u03ba\u03c4\u03cc\u03b6\u03b7<\/u><\/p>\n<p class=\"western\" lang=\"el-GR\">\u0397 \u03bb\u03b1\u03ba\u03c4\u03cc\u03b6\u03b7 \u03bc\u03b5 \u03c4\u03b7 \u03b2\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b6\u03cd\u03bc\u03bf\u03c5 \u03bb\u03b1\u03ba\u03c4\u03ac\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03ad\u03c0\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b3\u03b1\u03bb\u03b1\u03ba\u03c4\u03cc\u03b6\u03b7 \u03ba\u03b1\u03b9 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a3\u03b5 80% \u03c4\u03c9\u03bd \u03b5\u03bd\u03b7\u03bb\u03af\u03ba\u03c9\u03bd \u0395\u03c5\u03c1\u03c9\u03c0\u03b1\u03af\u03c9\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c0\u03b9\u03ba\u03c1\u03b1\u03c4\u03ae\u03c3\u03b5\u03b9 \u03ad\u03bd\u03b1 <u>\u03c3\u03bd\u03b9\u03c0<\/u> (<span lang=\"en-US\">SNP<\/span>) \u03c3\u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 -13,910 \u03c4\u03bf\u03c5 \u03b9\u03bd\u03c4\u03c1\u03bf\u03bd\u03af\u03bf\u03c5 13 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf\u03c5 <span lang=\"en-US\">MCM<\/span><span lang=\"fr-FR\">6<\/span>, \u03c0\u03bf\u03c5 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c0\u03cc\u03c3\u03c4\u03b1\u03c3\u03b7 1,9 <span lang=\"en-US\">kb<\/span> \u03b1\u03c0\u03cc \u03c4\u03bf \u03b5\u03be\u03cc\u03bd\u03b9\u03bf 1 \u03c4\u03bf\u03c5 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03bb\u03b1\u03ba\u03c4\u03ac\u03c3\u03b7\u03c2. \u0397 \u03ba\u03c5\u03c4\u03bf\u03c3\u03af\u03bd\u03b7 <span lang=\"en-US\">C<\/span> \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03af\u03c3\u03c4\u03b1\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b8\u03c5\u03bc\u03af\u03bd\u03b7 \u03a4, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b1 \u03bf\u03bc\u03bf\u03b6\u03cd\u03b3\u03c9\u03c4\u03ac \u03ac\u03c4\u03bf\u03bc\u03b1 \u03a4\u03a4 \u03ae \u03c4\u03b1 \u03b5\u03c4\u03b5\u03c1\u03bf\u03b6\u03c5\u03b3\u03c9\u03c4\u03ac <span lang=\"en-US\">CT<\/span> \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae \u03ba\u03b1\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03bb\u03b1\u03ba\u03c4\u03ac\u03c3\u03b7\u03c2. \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1 \u03c3\u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03bc\u03bf\u03b6\u03c5\u03b3\u03c9\u03c4\u03ac <span lang=\"en-US\">CC<\/span> \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03ad\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7 \u03bb\u03b1\u03ba\u03c4\u03ac\u03c3\u03b7\u03c2, \u03b7 \u03bb\u03b1\u03ba\u03c4\u03cc\u03b6\u03b7 \u03b4\u03b5\u03bd \u03b4\u03b9\u03b1\u03c3\u03c0\u03ac\u03c4\u03b1\u03b9, \u03b4\u03b5\u03bd \u03b1\u03c6\u03bf\u03bc\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03bf\u03c1\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c3\u03c4\u03bf \u03c0\u03b1\u03c7\u03cd \u03ad\u03bd\u03c4\u03b5\u03c1\u03bf \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ce\u03bd\u03c4\u03b1\u03c2 \u03b4\u03b9\u03ac\u03c1\u03c1\u03bf\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1 \u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1. \u0391\u03bd \u03b7 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03b4\u03b5\u03bd \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 \u03bb\u03b1\u03ba\u03c4\u03cc\u03b6\u03b7 \u03b4\u03b5\u03bd \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03c5\u03c0\u03b9\u03ba\u03ac \u03b7 \u03bd\u03cc\u03c3\u03bf\u03c2.<\/p>\n<p class=\"western\" lang=\"el-GR\"><u>3 \u039a\u03bf\u03b9\u03bb\u03b9\u03bf\u03ba\u03ac\u03ba\u03b7<\/u><\/p>\n<p class=\"western\" lang=\"el-GR\">\u0397 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03b3\u03bb\u03b9\u03b1\u03b4\u03af\u03bd\u03b7 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03c4\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b4\u03b7\u03bc\u03b7\u03c4\u03c1\u03b9\u03b1\u03ba\u03ac \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03c4\u03c1\u03b1\u03bd\u03c3\u03b3\u03bb\u03bf\u03c5\u03c4\u03b1\u03bc\u03b9\u03bd\u03ac\u03c3\u03b7. \u039f\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03ba\u03bf\u03b9\u03bb\u03b9\u03bf\u03ba\u03ac\u03ba\u03b7 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03b1\u03bb\u03bb\u03b7\u03bb\u03cc\u03bc\u03bf\u03c1\u03c6\u03bf HLA-DQ2 \u03ae \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c5\u03c7\u03bd\u03ac \u03c4\u03bf\u03bd HLA-DQ8 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7\u03bd \u03b3\u03bb\u03b9\u03b1\u03b4\u03af\u03bd\u03b7 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bc\u03af\u03b1 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03ba\u03bf\u03c0\u03ae \u03c4\u03c9\u03bd \u03bb\u03b1\u03c7\u03bd\u03ce\u03bd \u03c4\u03bf\u03c5 \u03bb\u03b5\u03c0\u03c4\u03bf\u03cd \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5. \u0391\u03bd \u03b7 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03b4\u03b5\u03bd \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 \u03b3\u03bb\u03bf\u03c5\u03c4\u03ad\u03bd\u03b7, \u03c4\u03cc\u03c4\u03b5 \u03b4\u03b5\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/p>\n<p class=\"western\" lang=\"el-GR\"><u>4 \u0391\u03bb\u03ba\u03bf\u03cc\u03bb <\/u><\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03b1\u03bb\u03ba\u03bf\u03bf\u03bb\u03b9\u03ba\u03ae \u03b1\u03c6\u03c5\u03b4\u03c1\u03bf\u03b3\u03bf\u03bd\u03ac\u03c3\u03b7 (\u0391<span lang=\"en-US\">DH<\/span>) \u03ba\u03b1\u03c4\u03b1\u03bb\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u03b1\u03b9\u03b8\u03c5\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bb\u03ba\u03bf\u03cc\u03bb\u03b7\u03c2 \u03c3\u03b5 \u03b1\u03ba\u03b5\u03c4\u03b1\u03bb\u03b4\u03b5\u03cd\u03b4\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03b1\u03c6\u03c5\u03b4\u03c1\u03bf\u03b3\u03bf\u03bd\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03ba\u03b5\u03c4\u03b1\u03bb\u03b4\u03b5\u03b0\u03b4\u03b7\u03c2 (A<b>L<\/b>D\u0397) \u03c4\u03b7\u03bd \u03bf\u03be\u03b5\u03af\u03b4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03ba\u03b5\u03c4\u03b1\u03bb\u03b4\u03b5\u03b0\u03b4\u03b7\u03c2.<\/p>\n<p lang=\"el-GR\">\u03a3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c5\u03ba\u03ac\u03c3\u03b9\u03b1 \u03c6\u03c5\u03bb\u03ae \u03c5\u03c0\u03b5\u03c1\u03c4\u03b5\u03c1\u03bf\u03cd\u03bd \u03bf\u03b9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03cc\u03bc\u03bf\u03c1\u03c6\u03bf\u03b9 ADH1B*1 \u03ae ADH1C*2 \u03bc\u03b5 \u03b1\u03c1\u03b3\u03ae \u03b5\u03bd\u03b6\u03c5\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 ALDH1A1*2 \u03bc\u03b5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03bd\u03b6\u03c5\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7. \u039f\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 \u03b1\u03c3\u03b9\u03ac\u03c4\u03b5\u03c2 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03bf\u03c5\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03cc\u03bc\u03bf\u03c1\u03c6\u03bf\u03c5\u03c2 ADH1B*2 \u03ba\u03b1\u03b9 ADH1C*1 \u03c0\u03bf\u03c5 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03b5\u03bd\u03b6\u03c5\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 ALDH1A2*2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03b5\u03c0\u03b1\u03c1\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b1\u03ba\u03b5\u03c4\u03b1\u03bb\u03b4\u03b5\u03b0\u03b4\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ae \u03bd\u03b1 \u03c3\u03c5\u03c3\u03c3\u03c9\u03c1\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9. \u0397 \u03b1\u03ba\u03b5\u03c4\u03b1\u03bb\u03b4\u03b5\u03b0\u03b4\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c0\u03b5\u03cd\u03b8\u03c5\u03bd\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03bf\u03b9\u03bd\u03bf\u03c0\u03bd\u03b5\u03cd\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03bf\u03bd \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc. \u0395\u03bd\u03bd\u03bf\u03b5\u03af\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b5\u03ac\u03bd \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bb\u03ae\u03c8\u03b7 \u03bf\u03b9\u03bd\u03bf\u03c0\u03bd\u03b5\u03cd\u03bc\u03b1\u03c4\u03bf\u03c2, \u03c4\u03cc\u03c4\u03b5 \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b7 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1.<\/p>\n<p class=\"western\" lang=\"el-GR\"><u>5 \u039a\u03b1\u03c6\u03b5\u03af\u03bd\u03b7 <\/u><\/p>\n<p class=\"western\" lang=\"el-GR\">\u0397 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03ba\u03c5\u03c4\u03cc\u03c7\u03c1\u03c9\u03bc\u03b1 450 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1. \u039f \u03b1\u03bb\u03bb\u03b7\u03bb\u03cc\u03bc\u03bf\u03c1\u03c6\u03bf\u03c2 CYP1A2 \u03bf\u03bc\u03bf\u03b6\u03c5\u03b3\u03c9\u03c4\u03cc\u03c2 -163\u0391 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b5\u03bd\u03b6\u03c5\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae, \u03b5\u03bd\u03ce \u03bf CYP1A2 -163<span lang=\"en-US\">C<\/span> \u03bc\u03b9\u03ba\u03c1\u03ae. \u03a4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b5\u03bd\u03b6\u03c5\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03c7\u03c1\u03cc\u03bd\u03bf \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u03af\u03bd\u03b7\u03c2 \u03c3\u03c4\u03bf\u03bd \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03ba\u03b1\u03b9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b5\u03bc\u03c6\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03af\u03bf\u03c5.<\/p>\n<p class=\"western\" lang=\"el-GR\"><u>6 \u03a6\u03bf\u03bb\u03b9\u03ba\u03cc \u03bf\u03be\u03cd <\/u><\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a4\u03bf \u03c6\u03bf\u03bb\u03b9\u03ba\u03cc \u03bf\u03be\u03cd (\u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7 \u03929) \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03ad\u03c0\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03a4\u0397<span lang=\"en-US\">F<\/span> (<span lang=\"en-US\">tetrahydro<\/span> <span lang=\"en-US\">folate<\/span>) \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03cc \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03b5\u03b9\u03c1\u03ac \u03c4\u03bf\u03c5 \u03c3\u03b5 5,10 <span lang=\"en-US\">M<\/span>&#8211;<span lang=\"en-US\">THF<\/span> (5,10-methylene tetrahydrofolate).<\/p>\n<p class=\"western\" lang=\"el-GR\"><span lang=\"en-US\">To<\/span> \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf <span lang=\"en-US\">MTHFR<\/span> (<span lang=\"en-US\">MTHF<\/span> <span lang=\"en-US\">Reductase<\/span>) \u03ba\u03b1\u03c4\u03b1\u03bb\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c0\u03ae \u03c4\u03bf\u03c5 5,10 <span lang=\"en-US\">M<\/span>&#8211;<span lang=\"en-US\">THF<\/span> \u03c3\u03b5 5 \u039c\u03a4\u0397<span lang=\"en-US\">F<\/span> (5-<span lang=\"en-US\">methyl<\/span> <span lang=\"en-US\">tetrahydrofolate<\/span>) \u03ba\u03b1\u03b9 \u03c4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf 5 \u039c\u03a4\u0397<span lang=\"en-US\">F<\/span> \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03bf\u03bc\u03bf\u03ba\u03c5\u03c3\u03c4\u03b5\u03ca\u03bd\u03b7 \u03c3\u03b5 \u03bc\u03b5\u03b8\u03b9\u03bf\u03bd\u03af\u03bd\u03b7.<\/p>\n<p class=\"western\" lang=\"el-GR\"><a href=\"https:\/\/armonia-zoi.gr\/wp-content\/uploads\/2015\/06\/\u03a7\u0397\u039c\u0399\u039a\u0397-\u0391\u039d\u03a4\u0399\u0394\u03a1\u0391\u03a3\u0397-1-\u039a\u0391\u0399-2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-937\" src=\"https:\/\/armonia-zoi.gr\/wp-content\/uploads\/2015\/06\/\u03a7\u0397\u039c\u0399\u039a\u0397-\u0391\u039d\u03a4\u0399\u0394\u03a1\u0391\u03a3\u0397-1-\u039a\u0391\u0399-2-300x53.jpg\" alt=\"\u03a7\u0397\u039c\u0399\u039a\u0397 \u0391\u039d\u03a4\u0399\u0394\u03a1\u0391\u03a3\u0397 1 \u039a\u0391\u0399 2\" width=\"351\" height=\"80\" \/><\/a><\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03bf \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b6\u03cd\u03bc\u03bf\u03c5 <span lang=\"en-US\">MTHF<\/span> <span lang=\"en-US\">Reductase<\/span> \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c7\u03c1\u03c9\u03bc\u03cc\u03c3\u03c9\u03bc\u03b1 1. \u039f\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03bf 677 \u03c4\u03b7\u03bd \u03b2\u03ac\u03c3\u03b7 \u03ba\u03c5\u03c4\u03bf\u03c3\u03af\u03bd\u03b7 (677<span lang=\"en-US\">C<\/span>), \u03c0\u03bf\u03c5 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b5\u03bd\u03b6\u03cd\u03bc\u03bf\u03c5 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd, \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03c4\u03bf \u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03cd \u03b1\u03bb\u03b1\u03bd\u03af\u03bd\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b8\u03ad\u03c3\u03b7 222 (222<span lang=\"en-US\">Ala<\/span>). \u03a3\u03b5 10-15% \u03c4\u03c9\u03bd \u0395\u03c5\u03c1\u03c9\u03c0\u03b1\u03af\u03c9\u03bd \u03cc\u03bc\u03c9\u03c2 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bf \u03b1\u03bb\u03bb\u03b7\u03bb\u03cc\u03bc\u03bf\u03c1\u03c6\u03bf\u03c2 677\u03a4 \u03bc\u03b5 \u03b8\u03c5\u03bc\u03af\u03bd\u03b7 \u03c3\u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 677 \u03b1\u03bd\u03c4\u03af \u03c4\u03b7\u03c2 \u03ba\u03c5\u03c4\u03bf\u03c3\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b5\u03bd\u03b6\u03cd\u03bc\u03bf\u03c5 222<span lang=\"en-US\">Val<\/span>, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03bc\u03b5 \u03b2\u03b1\u03bb\u03af\u03bd\u03b7 \u03b1\u03bd\u03c4\u03af \u03b3\u03b9\u03b1 \u03b1\u03bb\u03b1\u03bd\u03af\u03bd\u03b7. \u03a4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03bc\u03b5 222<span lang=\"en-US\">Val<\/span> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b8\u03b5\u03c1\u03bc\u03bf\u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03bf \u03ba\u03b1\u03b9 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac 65%, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03bc\u03cc\u03b6\u03c5\u03b3\u03bf \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bb\u03cd\u03b5\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u03bf\u03bc\u03bf\u03ba\u03c5\u03c3\u03c4\u03b5\u03af\u03bd\u03b7\u03c2 \u03c3\u03b5 \u03bc\u03b5\u03b8\u03b9\u03bf\u03bd\u03af\u03bd\u03b7, \u03bf\u03c0\u03cc\u03c4\u03b5 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03b5\u03b9 \u03c3\u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03b1\u03c5\u03c4\u03ac \u03b5\u03bb\u03b1\u03c6\u03c1\u03ac \u03c5\u03c0\u03b5\u03c1 \u03bf\u03bc\u03bf\u03ba\u03c5\u03c3\u03c4\u03b5\u03ca\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03b8\u03b7\u03c1\u03bf\u03b3\u03cc\u03bd\u03bf \u03b4\u03c1\u03ac\u03c3\u03b7. \u0391\u03c5\u03c4\u03cc \u03b5\u03c0\u03b9\u03c4\u03b5\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03b7 \u03c4\u03c1\u03bf\u03c6\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c4\u03c9\u03c7\u03ae \u03c3\u03b5 \u03c6\u03bf\u03bb\u03b9\u03ba\u03cc \u03bf\u03be\u03cd \u03ba\u03b1\u03b9 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c6\u03bf\u03bb\u03b9\u03ba\u03bf\u03cd \u03bf\u03be\u03ad\u03c9\u03c2.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1: \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c6\u03c5\u03bb\u03ad\u03c2, \u03ae \u03c5\u03c0\u03bf\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03b9\u03b1 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03b9\u03b4\u03b9\u03b1\u03b9\u03c4\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03bd\u03cc\u03c3\u03bf\u03c5, \u03bc\u03cc\u03bd\u03bf\u03bd \u03b5\u03ac\u03bd \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd \u03c4\u03b9\u03c2 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b5\u03b9\u03b5\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03bb\u03b5\u03b9\u03bf\u03c8\u03b7\u03c6\u03af\u03b1\u03c2, \u03ae \u03ac\u03bb\u03bb\u03b5\u03c2 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b5\u03b9\u03b5\u03c2 \u00ab\u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2\u00bb. \u0397 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03c3\u03b5 \u03c5\u03c0\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03b1\u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03b5\u03ac\u03bd \u03b7 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03bf\u03c5\u03c2 \u03b4\u03b5\u03bd \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03c4\u03c1\u03bf\u03c6\u03ae \u03ae \u03b5\u03ac\u03bd \u03b1\u03c5\u03c4\u03ae \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03ae \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1.<\/p>\n<p class=\"western\" lang=\"el-GR\">* \u0394\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u039f\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2, \u03b1\u03bb\u03bb\u03ac \u03c4\u03c1\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 \u03c0\u03b5\u03b4\u03af\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03bb\u03bf\u03c5\u03c3\u03b9\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1.<\/p>\n<p class=\"western\" lang=\"el-GR\"><u>1 <\/u><span lang=\"en-US\"><u>ApoAII<\/u><\/span><u> <\/u>(\u0391\u03c0\u03bf\u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u03af\u03bd\u03b7 \u0391\u0399\u0399)<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0397 <span lang=\"en-US\">Apo<\/span>\u0391\u0399\u0399 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b7 \u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c4\u03b7\u03c2 <span lang=\"en-US\">HDL<\/span> \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2. \u03a4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u0391poA2 \u03c0\u03bf\u03c5 \u03c4\u03b7\u03bd \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c7\u03c1\u03c9\u03bc\u03cc\u03c3\u03c9\u03bc\u03b1 1. \u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03c4\u03bf\u03c5 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae (<span lang=\"en-US\">promoter<\/span>) \u03c3\u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 265 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b8\u03c5\u03bc\u03af\u03bd\u03b7 \u03a4. \u03a3\u03c4\u03b9\u03c2 \u0397\u03a0\u0391 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u039c\u03b5\u03c3\u03bf\u03b3\u03b5\u03b9\u03b1\u03ba\u03ad\u03c2 \u03c7\u03ce\u03c1\u03b5\u03c2 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ac \u03cc\u03bc\u03c9\u03c2 \u03c3\u03b5 11-15% \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03ba\u03b1\u03b9 \u03bf \u03b1\u03bb\u03bb\u03b7\u03bb\u03cc\u03bc\u03bf\u03c1\u03c6\u03bf\u03c2 <span lang=\"en-US\">CC<\/span> \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03cd\u03bf \u03ba\u03c5\u03c4\u03bf\u03c3\u03af\u03bd\u03b5\u03c2 <span lang=\"en-US\">CC<\/span> \u03ba\u03b1\u03b9 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc 30% \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b5\u03c1\u03b9\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 <span lang=\"en-US\">Apo<\/span>\u0391\u0399\u0399 \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1. \u03a4\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03cc\u03bc\u03c9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03cc\u03c4\u03b1\u03bd \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf\u03bd \u03b1\u03bb\u03bb\u03b7\u03bb\u03cc\u03bc\u03bf\u03c1\u03c6\u03bf \u0391poA2 265 <span lang=\"en-US\">CC<\/span>, \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c9\u03c2 \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03cc\u03c2 -265<span lang=\"en-US\">T<\/span>&gt;<span lang=\"en-US\">C<\/span>, \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03c0\u03bb\u03bf\u03cd\u03c3\u03b9\u03b1 \u03c3\u03b5 \u03ba\u03b5\u03ba\u03bf\u03c1\u03b5\u03c3\u03bc\u03ad\u03bd\u03b1 \u03bb\u03af\u03c0\u03b7 (&gt; 22 \u03b3\u03c1\/\u03bc) \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd 6,8% \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u0392\u039c\u0399 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b1\u03bb\u03bb\u03b7\u03bb\u03cc\u03bc\u03bf\u03c1\u03c6\u03bf \u03a4<span lang=\"en-US\">C<\/span> \u03ae \u03a4\u03a4 (1).<\/p>\n<p class=\"western\" lang=\"el-GR\"><span lang=\"en-GB\"><u>2 PPAR-<\/u><\/span><u>\u03b3<\/u><span lang=\"en-GB\"> (<\/span><span lang=\"en-US\">Peroxisome proliferator activator receptor-<\/span>\u03b3<span lang=\"en-GB\">)<\/span><\/p>\n<p class=\"western\" lang=\"el-GR\">\u039f PPAR-\u03b3 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03c0\u03c5\u03c1\u03b7\u03bd\u03b9\u03ba\u03cc\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2, \u03c0\u03bf\u03c5 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03c4\u03b1 \u03bb\u03b9\u03c0\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03bc\u03c5\u03ca\u03ba\u03cc \u03b9\u03c3\u03c4\u03cc \u03ba\u03b1\u03b9 \u03c4\u03bf \u03ae\u03c0\u03b1\u03c1. \u0388\u03bd\u03b1\u03c2 \u03c3\u03c5\u03bd\u03b4\u03ad\u03c4\u03b7\u03c2 (<span lang=\"en-US\">ligand<\/span>), \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03ad\u03bd\u03b1 \u03bb\u03b9\u03c0\u03b1\u03c1\u03cc \u03bf\u03be\u03cd, \u03c0\u03c1\u03bf\u03c3\u03b4\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd <span lang=\"en-US\">PPAR<\/span>\u03b3 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af. \u039f <span lang=\"en-US\">PPR<\/span>\u03b3 \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03af\u03b6\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03b4\u03b9\u03bc\u03b5\u03c1\u03ad\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c1\u03b5\u03c4\u03b9\u03bd\u03bf\u03ca\u03ba\u03cc \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 <span lang=\"en-US\">RXR<\/span>. <span lang=\"en-US\">To<\/span> \u03c3\u03cd\u03bc\u03c0\u03bb\u03b5\u03b3\u03bc\u03b1 <span lang=\"en-US\">PPAR<\/span>\u03b3-<span lang=\"en-US\">RXR<\/span> \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03ad\u03bd\u03b1\u03bd \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae (<span lang=\"en-US\">promoter<\/span>) \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae\u03c2 \u03c4\u03bf\u03c5 <span lang=\"en-US\">DNA<\/span>, \u03c4\u03bf\u03bd <span lang=\"en-US\">PPRE<\/span>. \u039f PPAR-\u03b3 \u03c0\u03c1\u03bf\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03bb\u03b9\u03c0\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03bb\u03b9\u03c0\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03cc\u03bc\u03bf\u03c1\u03c6\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03b5\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c4\u03bf \u03ba\u03c9\u03b4\u03b9\u03ba\u03cc\u03bd\u03b9\u03bf 12 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03b8\u03b5\u03af \u03b7 \u03c0\u03c1\u03bf\u03bb\u03af\u03bd\u03b7 (<span lang=\"en-US\">Pro<\/span>) \u03b1\u03c0\u03cc \u03bc\u03b9\u03b1 \u03b1\u03bb\u03b1\u03bd\u03af\u03bd\u03b7 (<span lang=\"en-US\">Ala<\/span>). \u03a4\u03bf \u0392\u039c\u0399 \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03bc\u03b5 PPAR-\u03b3 Pro12Ala \u03cc\u03c4\u03b1\u03bd \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03c0\u03bb\u03bf\u03cd\u03c3\u03b9\u03b1 \u03c3\u03b5 \u03bb\u03b9\u03c0\u03b1\u03c1\u03ac \u03b4\u03b5\u03bd \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03cc\u03c3\u03bf \u03cc\u03c3\u03bf \u03c4\u03c9\u03bd \u03bf\u03bc\u03bf\u03b6\u03c5\u03b3\u03c9\u03c4\u03b9\u03ba\u03ce\u03bd PPAR-\u03b3 <span lang=\"en-US\">Pro<\/span>\/<span lang=\"en-US\">Pro<\/span>, \u03ba\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03cc\u03c4\u03b1\u03bd \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03bc\u03bf\u03bd\u03bf\u03b1\u03ba\u03cc\u03c1\u03b5\u03c3\u03c4\u03b1 \u03bb\u03b9\u03c0\u03b1\u03c1\u03ac \u03c4\u03bf \u0392\u039c\u0399 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 (2).<\/p>\n<p class=\"western\" lang=\"el-GR\"><span lang=\"en-US\"><u>3 FTO<\/u><\/span><span lang=\"en-US\"> (Fat mass and obesity-associated) <\/span><\/p>\n<p class=\"western\" lang=\"el-GR\">\u039f FTO \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1\u03c2.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u039f \u03b1\u03bb\u03bb\u03b7\u03bb\u03cc\u03bc\u03bf\u03c1\u03c6\u03bf\u03c2 FTO rs9939609 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03c4\u03bf\u03c5 \u03c0\u03c1\u03ce\u03c4\u03bf\u03c5 \u03b9\u03bd\u03c4\u03c1\u03bf\u03bd\u03af\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03b1\u03bd\u03c4\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03cd\u03bf \u03b8\u03c5\u03bc\u03af\u03bd\u03b5\u03c2 \u03a4\u03a4 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c4\u03b5\u03c1\u03cc\u03b6\u03c5\u03b3\u03bf\u03c2 A\u03a4 \u03ae \u03bf\u03bc\u03cc\u03b6\u03c5\u03b3\u03bf\u03c2 \u0391\u0391 (\u03bc\u03b5 \u03b1\u03bb\u03b1\u03bd\u03af\u03bd\u03b7). \u03a3\u03c4\u03b9\u03c2 \u03b4\u03cd\u03bf \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03bf\u03b6\u03c5\u03b3\u03c9\u03c4\u03ae \u03bc\u03bf\u03c1\u03c6\u03ae \u0391\u0391 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03bb\u03ae\u03c8\u03b7 \u03b8\u03b5\u03c1\u03bc\u03af\u03b4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c0\u03ce\u03c2 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1\u03c2.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03bf \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03cc\u03bc\u03c9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c5\u03c0\u03b5\u03c1\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1\u03c2, \u03b5\u03bd\u03ce \u03b7 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae \u03ac\u03c3\u03ba\u03b7\u03c3\u03b7 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf (3, 4).<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1: \u03b7 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03c0\u03bb\u03bf\u03cd\u03c3\u03b9\u03b1 \u03c3\u03b5 \u03bb\u03af\u03c0\u03b7 \u03c0\u03c1\u03bf\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03c3\u03b5 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2, \u03b1\u03bb\u03bb\u03ac \u03c3\u03b5 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03c3\u03b5 \u03cc\u03c3\u03bf\u03c5\u03c2 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c4\u03bf\u03c5\u03bd \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03bf \u03b1\u03bb\u03bb\u03b7\u03bb\u03cc\u03bc\u03bf\u03c1\u03c6\u03bf. \u03a0\u03b9\u03bf \u03b5\u03c0\u03b9\u03c1\u03c1\u03b5\u03c0\u03ae \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c3\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd FTO rs9939609 \u0391\u0391, \u0391poA2 265 <span lang=\"en-US\">CC<\/span> \u03ba\u03b1\u03b9 PPAR-\u03b3 <span lang=\"en-US\">Pro<\/span>\/<span lang=\"en-US\">Pro<\/span>.<\/p>\n<p class=\"western\" lang=\"el-GR\"><b>2. \u0395\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae (<\/b><span lang=\"fr-FR\"><b>Epigenetics)<\/b><\/span><\/p>\n<p class=\"western\" lang=\"el-GR\">\u0395\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03c9\u03bd \u03b1\u03bb\u03bb\u03b1\u03b3\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1 \u03c4\u03bf\u03c5 DNA.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u039c\u03cc\u03bd\u03bf\u03bd 2% \u03c4\u03bf\u03c5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd. \u03a4\u03bf \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03bf 98% \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03c0\u03bf\u03c0\u03c4\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd. \u0395\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03bf\u03bd \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc. \u03a3\u03c4\u03bf\u03bd \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 200 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03c4\u03cd\u03c0\u03bf\u03c5 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c4\u03bf\u03c5\u03bd \u03cc\u03bb\u03b1 \u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03b1\u03ba\u03c1\u03b9\u03b2\u03ce\u03c2 <span lang=\"en-US\">DNA<\/span>. \u039a\u03ac\u03b8\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03b5\u03af\u03b4\u03bf\u03c2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5 \u03b1\u03c0\u03bf\u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03bc\u03cc\u03bd\u03bf \u03ad\u03bd\u03b1 \u03c4\u03bc\u03ae\u03bc\u03b1 \u03c4\u03bf\u03c5 <span lang=\"en-US\">DNA<\/span> \u03c0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03b1\u03c0\u03b5\u03af \u03b5\u03af\u03c4\u03b5 \u03c3\u03b5 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03cc, \u03b5\u03af\u03c4\u03b5 \u03c3\u03b5 \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc, \u03b5\u03af\u03c4\u03b5 \u03c3\u03b5 \u03bc\u03c5\u03ca\u03ba\u03cc \u03ba.\u03bf.\u03ba. \u03bc\u03b5 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a0\u03b5\u03c1\u03b9\u03b2\u03b1\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03bf\u03af \u03b5\u03be\u03c9\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03bf\u03c5\u03bd \u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c3\u03c4\u03bf \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bc\u03b1. \u039f \u03cc\u03c1\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03cc\u03bb\u03bf \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03ba\u03c6\u03c1\u03ac\u03c3\u03b5\u03b9 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u00ab\u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03ae \u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u00bb (<em>Developmental Plasticity). <\/em><\/p>\n<p class=\"western\" lang=\"el-GR\">\u0388\u03c4\u03c3\u03b9 \u03b5\u03be\u03b7\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bf\u03b9 \u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03c5\u03c0\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bf\u03bc\u03bf\u03b6\u03c5\u03b3\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b4\u03b9\u03b4\u03cd\u03bc\u03bf\u03c5\u03c2.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u039f\u03b9 \u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03b9\u03bc\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03ae\u03c3\u03b9\u03bc\u03b5\u03c2.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c4\u03c1\u03b5\u03b9\u03c2 \u03b2\u03b1\u03c3\u03b9\u03ba\u03bf\u03af \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae\u03c2.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0391. <u>\u0391\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7<\/u><\/p>\n<p class=\"western\" lang=\"el-GR\">\u0397 \u03ba\u03c5\u03c4\u03bf\u03c3\u03af\u03bd\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b5\u03af \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7, (\u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03bd\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b5\u03b8\u03b5\u03af \u03ad\u03bd\u03b1 \u03bc\u03b5\u03b8\u03cd\u03bb\u03b9\u03bf \u03c3\u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 5\u0384) \u03c7\u03ac\u03c1\u03b9\u03c2 \u03c3\u03c4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03bc\u03b5\u03b8\u03c5\u03bb\u03bf\u03c4\u03c1\u03b1\u03bd\u03c3\u03c6\u03b5\u03c1\u03ac\u03c3\u03b7 (<span style=\"font-family: AdvPSSAB-R, 'Times New Roman', serif;\"><span lang=\"es-ES\">DNA<\/span><\/span> <span style=\"font-family: AdvPSSAB-R, 'Times New Roman', serif;\"><span lang=\"es-ES\">methyltransferase<\/span><\/span> <span style=\"font-family: AdvPSSAB-R, 'Times New Roman', serif;\"><span lang=\"es-ES\">DNMT<\/span><\/span><span style=\"font-family: AdvPSSAB-R, 'Times New Roman', serif;\">)<\/span>, \u03bc\u03cc\u03bd\u03bf \u03b1\u03bd \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b3\u03bf\u03c5\u03b1\u03bd\u03af\u03bd\u03b7, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03b1 \u03b4\u03b9\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03b1 <span lang=\"en-US\">CpG<\/span>, \u03ba\u03b1\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c3\u03c4\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b1 <span lang=\"en-US\">CpG<\/span> \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c4\u03b1 \u03b4\u03b9\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03bb\u03ac, \u03cc\u03c0\u03c9\u03c2 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03c3\u03c4\u03b1 \u03bd\u03b7\u03c3\u03af\u03b4\u03b9\u03b1 <span lang=\"en-US\">CpG<\/span>. \u0388\u03c4\u03c3\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03b8\u03c5\u03bb\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 70-80% \u03c4\u03c9\u03bd \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03c9\u03bd <span lang=\"en-US\">CpG<\/span> \u03ba\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf 10% \u03c4\u03c9\u03bd <span lang=\"en-US\">CpG<\/span> \u03c4\u03c9\u03bd \u03bd\u03b7\u03c3\u03b9\u03b4\u03af\u03c9\u03bd.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0397 \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae \u03c4\u03bf\u03c5 <span lang=\"en-US\">DNA<\/span> \u03c3\u03b5 <span lang=\"en-US\">RNA<\/span> \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <span lang=\"en-US\">RNA<\/span> \u03c0\u03bf\u03bb\u03c5\u03bc\u03b5\u03c1\u03ac\u03c3\u03b7, \u03b1\u03bb\u03bb\u03ac \u03b5\u03c6\u2019 \u03cc\u03c3\u03bf\u03bd \u03c4\u03b1 \u03bc\u03b7 \u03bc\u03b5\u03b8\u03c5\u03bb\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03bd\u03b7\u03c3\u03af\u03b4\u03b9\u03b1 <span lang=\"en-US\">CpG<\/span> \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03bf\u03bd\u03c4\u03ac \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ad\u03c2 (<span lang=\"en-US\">promoters<\/span>) \u03b4\u03b5\u03bd \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a3\u03c5\u03bd\u03b5\u03c0\u03ce\u03c2, \u03b5\u03ac\u03bd \u03b1\u03c5\u03be\u03b7\u03b8\u03b5\u03af \u03c5\u03c0\u03ad\u03c1\u03bc\u03b5\u03c4\u03c1\u03b1 \u03b7 \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7. \u0391\u03c5\u03c4\u03cc \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03bb\u03cc \u03ae \u03ba\u03b1\u03ba\u03cc \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03b5\u03b9 \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03ae \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae \u03ba\u03b1\u03b9 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b9\u03c3\u03c4\u03cc \u03cc\u03c0\u03bf\u03c5 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9. \u0393\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u03b1\u03bd \u03b7 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03b1\u03b4\u03c1\u03b1\u03bd\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03bf\u03b3\u03ba\u03bf\u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c4\u03cc\u03c4\u03b5 \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7. \u0391\u03bd \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03b1\u03b4\u03c1\u03b1\u03bd\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03ad\u03bd\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03bf\u03b3\u03ba\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03cc \u03ae \u03ad\u03bd\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03bf <span lang=\"en-US\">DNA<\/span>-\u03b5\u03c0\u03b9\u03b4\u03b9\u03bf\u03c1\u03b8\u03c9\u03c4\u03b9\u03ba\u03cc \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0392. <span style=\"text-decoration: underline;\">\u0391\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03b9\u03c3\u03c4\u03cc\u03bd\u03b5\u03c2<\/span><\/p>\n<p class=\"western\" lang=\"el-GR\">\u0397 \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b9\u03c3\u03c4\u03bf\u03bd\u03ce\u03bd \u03973 \u039a\u0391\u0399 \u03974, \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03bb\u03c5\u03c3\u03af\u03bd\u03b5\u03c2 9 \u03ba\u03b1\u03b9 27 (\u03973\u039a9, \u03973\u039a27) \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03c3\u03c5\u03bc\u03c0\u03cd\u03ba\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae\u03c2, \u03b5\u03bd\u03ce \u03b7 \u03b1\u03ba\u03b5\u03c4\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03c7\u03b1\u03bb\u03ac\u03c1\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae\u03c2.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0393. <span style=\"text-decoration: underline;\">\u039c\u03b9\u03ba\u03c1\u03bf<span lang=\"en-US\">RNA<\/span> (<span lang=\"en-US\">miRNA<\/span>)<\/span><\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a4\u03b1 \u03bc\u03b9\u03ba\u03c1\u03bf<span lang=\"en-US\">RNA<\/span> \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b1\u03c0\u03cc 22 \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03b1. \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03bc\u03b7 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03bc\u03bf\u03bd\u03ae\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1\u03c2 RNA, \u03c0\u03bf\u03c5 \u03cc\u03bc\u03c9\u03c2 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf <span lang=\"en-US\">mRNA<\/span> \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c6\u03c1\u03b1\u03c3\u03c4\u03b5\u03af \u03c3\u03c4\u03bf \u03c1\u03b9\u03b2\u03cc\u03c3\u03c9\u03bc\u03b1. \u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03b5\u03ba\u03b1\u03c4\u03bf\u03bd\u03c4\u03ac\u03b4\u03b5\u03c2 <span lang=\"en-US\">miRNA<\/span>, \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b4\u03b5\u03b8\u03bf\u03cd\u03bd \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03c4\u03bc\u03ae\u03bc\u03b1\u03c4\u03b1 <span lang=\"en-US\">mRNA<\/span>.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u039f\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03b5\u03bc\u03b2\u03c1\u03c5\u03ca\u03ba\u03ae \u03c0\u03b5\u03c1\u03af\u03bf\u03b4\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03bd\u03b5\u03bf\u03b3\u03bd\u03b9\u03ba\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b5\u03ac\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b3\u03b1\u03bb\u03bf\u03c5\u03c7\u03af\u03b1. \u0391\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03cc\u03bc\u03c9\u03c2 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03b1\u03c1\u03b3\u03cc\u03c4\u03b5\u03c1\u03b1. \u0388\u03c1\u03b5\u03c5\u03bd\u03b5\u03c2 \u03c3\u03b5 \u03bf\u03bc\u03bf\u03b6\u03c5\u03b3\u03c9\u03c4\u03ac \u03b4\u03af\u03b4\u03c5\u03bc\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03c3\u03b5 \u03bd\u03b5\u03b1\u03c1\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03bc\u03b9\u03ba\u03c1\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03c3\u03c4\u03b7\u03bd \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7, \u03c0\u03bf\u03c5 \u03bc\u03b5\u03b3\u03b1\u03bb\u03ce\u03bd\u03bf\u03c5\u03bd \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03cc\u03c4\u03b1\u03bd \u03b6\u03bf\u03cd\u03c3\u03b1\u03bd \u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03ac. \u0397 \u03b3\u03ae\u03c1\u03b1\u03bd\u03c3\u03b7 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c5\u03c0\u03bf\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 <span lang=\"en-US\">DNA<\/span>, \u03b1\u03bb\u03bb\u03ac \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ce\u03bd (<span lang=\"en-US\">promoters<\/span>).<\/p>\n<p class=\"western\" lang=\"el-GR\">\u039c\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03b2\u03b1\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bc\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b8\u03ad\u03c3\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03bf \u03ba\u03ac\u03c0\u03bd\u03b9\u03c3\u03bc\u03b1, \u03bf\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b2\u03b1\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c1\u03cd\u03c0\u03b1\u03bd\u03c3\u03b7\u03c2, \u03b7 \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ac \u03b7 \u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae \u03c7\u03bb\u03c9\u03c1\u03af\u03b4\u03b1 (<span lang=\"en-US\">microbiota<\/span>).<\/p>\n<p class=\"western\" lang=\"el-GR\"><b>4. \u0394\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b3\u03b5\u03bd\u03c9\u03bc\u03b9\u03ba\u03ae <\/b><\/p>\n<p class=\"western\" lang=\"el-GR\">\u0394\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b3\u03b5\u03bd\u03c9\u03bc\u03b9\u03ba\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03c9\u03bd \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03c9\u03bd \u03c4\u03c1\u03bf\u03c6\u03ce\u03bd \u03c3\u03c4\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf \u03bc\u03b5 \u03c4\u03bf\u03bd \u03bf\u03c0\u03bf\u03af\u03bf \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03ac \u03bc\u03b1\u03c2. \u0395\u03af\u03bd\u03b1\u03b9 \u03c4\u03c1\u03cc\u03c0\u03bf\u03bd \u03c4\u03b9\u03bd\u03ac \u03b7 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03bf\u03bc\u03ac\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0397 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 <span lang=\"en-US\">DNA<\/span>, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03ba\u03b5\u03c4\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b9\u03c3\u03c4\u03cc\u03bd\u03c9\u03bd \u03b5\u03af\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03c7\u03ae \u03bc\u03b5\u03b8\u03c5\u03bb\u03b9\u03bf\u03b4\u03bf\u03c4\u03ce\u03bd, \u03b5\u03af\u03c4\u03b5 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b1 \u03b5\u03bc\u03c0\u03bb\u03b5\u03ba\u03cc\u03bc\u03b5\u03bd\u03b1 \u03ad\u03bd\u03b6\u03c5\u03bc\u03b1. \u039f\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2, \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c6\u03bf\u03bb\u03b9\u03ba\u03cc \u03bf\u03be\u03cd, \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c3\u03b5\u03bb\u03ae\u03bd\u03b9\u03bf, \u03b7 <span lang=\"en-US\">Genistein<\/span>, \u03bf\u03b9 \u03c0\u03bf\u03bb\u03c5\u03c6\u03b5\u03bd\u03cc\u03bb\u03b5\u03c2 \u03ba\u03b1\u03b9, \u03c3\u03b5 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc, \u03bf\u03b9 \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b5\u03c2 \u03926 \u03ba\u03b1\u03b9 \u039212, \u03b7 \u03c7\u03bf\u03bb\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03bf \u03c8\u03b5\u03c5\u03b4\u03ac\u03c1\u03b3\u03c5\u03c1\u03bf\u03c2.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0395\u03af\u03b4\u03b1\u03bc\u03b5 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf 5 \u039c\u03a4\u0397<span lang=\"en-US\">F<\/span> \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03bf\u03bc\u03bf\u03ba\u03c5\u03c3\u03c4\u03b5\u03ca\u03bd\u03b7 \u03c3\u03b5 \u03bc\u03b5\u03b8\u03b9\u03bf\u03bd\u03af\u03bd\u03b7.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0391\u03c0\u03cc \u03c4\u03b7\u03bd \u03bc\u03b5\u03b8\u03b9\u03bf\u03bd\u03af\u03bd\u03b7 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03b5\u03b9 \u03b7 <span lang=\"en-GB\">S<\/span><span style=\"font-family: AdvPSSAB-I, Arial, sans-serif;\">&#8211;<\/span><span style=\"font-family: AdvPSSAB-R, 'Times New Roman', serif;\"><span lang=\"en-GB\">adenosyl<\/span><\/span> <span style=\"font-family: AdvPSSAB-R, 'Times New Roman', serif;\"><span lang=\"en-GB\">methionine<\/span><\/span><span style=\"font-family: AdvPSSAB-R, 'Times New Roman', serif;\"> (<\/span><span style=\"font-family: AdvPSSAB-R, 'Times New Roman', serif;\"><span lang=\"en-GB\">SAM<\/span><\/span><span style=\"font-family: AdvPSSAB-R, 'Times New Roman', serif;\">)<\/span>, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03c0\u03b7\u03b3\u03ae \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03bd \u03bc\u03ad\u03c3\u03c9 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b6\u03cd\u03bc\u03bf\u03c5 <span style=\"font-family: AdvPSSAB-R, 'Times New Roman', serif;\"><span lang=\"es-ES\">DNA<\/span><\/span> <span style=\"font-family: AdvPSSAB-R, 'Times New Roman', serif;\"><span lang=\"es-ES\">methyl transferase<\/span><\/span><span style=\"font-family: AdvPSSAB-R, 'Times New Roman', serif;\"> (<\/span><span style=\"font-family: AdvPSSAB-R, 'Times New Roman', serif;\"><span lang=\"es-ES\">DNMT<\/span><\/span><span style=\"font-family: AdvPSSAB-R, 'Times New Roman', serif;\">)<\/span>, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 <span lang=\"en-US\">DNA<\/span>.<\/p>\n<p class=\"western\" lang=\"el-GR\"><a href=\"https:\/\/armonia-zoi.gr\/wp-content\/uploads\/2015\/06\/\u03a7\u0397\u039c\u0399\u039a\u0397-\u0391\u039d\u03a4\u0399\u0394\u03a1\u0391\u03a3\u0397-3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-938\" src=\"https:\/\/armonia-zoi.gr\/wp-content\/uploads\/2015\/06\/\u03a7\u0397\u039c\u0399\u039a\u0397-\u0391\u039d\u03a4\u0399\u0394\u03a1\u0391\u03a3\u0397-3-300x24.jpg\" alt=\"\u03a7\u0397\u039c\u0399\u039a\u0397 \u0391\u039d\u03a4\u0399\u0394\u03a1\u0391\u03a3\u0397 3\" width=\"327\" height=\"45\" \/><\/a><\/p>\n<p class=\"western\" lang=\"el-GR\">*\u0394\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b3\u03b5\u03bd\u03c9\u03bc\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a4\u03b1 \u03b5\u03c1\u03c9\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03c4\u03af\u03b8\u03b5\u03bd\u03c4\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 \u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b1:<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a0\u03ce\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03b7 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7;<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a0\u03bf\u03b9\u03ac \u03c3\u03b7\u03bc\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2, \u03b5\u03ac\u03bd \u03bc\u03b5\u03b8\u03c5\u03bb\u03b9\u03c9\u03b8\u03bf\u03cd\u03bd, \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1;<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a0\u03ce\u03c2 \u03b7 \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03b5 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1;<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 \u201c\u03c0\u03b1\u03af\u03ba\u03c4\u03b5\u03c2\u201d \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03c3\u03b5\u03c2 \u03ad\u03c9\u03c2 \u03c4\u03ce\u03c1\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b1\u03bd\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c4\u03b7\u03c2 <span lang=\"en-US\">POMC<\/span>, \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03c9\u03bd \u03b3\u03bb\u03c5\u03ba\u03bf\u03ba\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2.<\/p>\n<p class=\"western\"><b>POMC<\/b><\/p>\n<p class=\"western\" lang=\"el-GR\">\u0397 <span lang=\"en-US\">POMC<\/span> \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03bf\u03c1\u03b5\u03be\u03b9\u03bf\u03b3\u03cc\u03bd\u03bf \u03b4\u03c1\u03ac\u03c3\u03b7, \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf \u03bd\u03b5\u03c5\u03c1\u03bf\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03a5 (<span lang=\"en-US\">NPY<\/span>) \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03bf\u03c1\u03b5\u03be\u03b9\u03bf\u03b3\u03cc\u03bd\u03bf. \u03a3\u03b5 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bf \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae\u03c2 <span lang=\"en-US\">promoter<\/span> \u03c4\u03b7\u03c2 <span lang=\"en-US\">POMC<\/span> \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 404 \u03b6\u03b5\u03c5\u03b3\u03ac\u03c1\u03b9\u03b1 \u03b2\u03ac\u03c3\u03b5\u03c9\u03bd \u03b5\u03ba \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd 21 \u03b5\u03af\u03bd\u03b1\u03b9 <span lang=\"en-US\">CpG<\/span> \u03b4\u03b9\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03b1. \u03a5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03af\u03b1 \u03c4\u03bf\u03c0\u03bf\u03b8\u03b5\u03c3\u03af\u03b1 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2 (<span lang=\"en-US\">binding<\/span> <span lang=\"en-US\">site<\/span>) \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae\u03c2 \u03c4\u03b7\u03c2 <span lang=\"en-US\">POMC<\/span> \u03ba\u03b1\u03b9 4 \u03c4\u03bf\u03c0\u03bf\u03b8\u03b5\u03c3\u03af\u03b5\u03c2 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2 (<span lang=\"en-US\">binding<\/span> <span lang=\"en-US\">site<\/span>) \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae\u03c2. \u0391\u03c0\u03cc \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c4\u03b9\u03c2 4 \u03bf\u03b9 \u03b4\u03cd\u03bf \u03c3\u03c0\u03bf\u03c5\u03b4\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u039d<span lang=\"en-US\">F<\/span>&#8211;<span lang=\"en-US\">kB<\/span> \u03ba\u03b1\u03b9 \u03b7 <span lang=\"en-US\">S<\/span><span lang=\"fr-FR\">p<\/span>1. \u0397 <span lang=\"en-US\">S<\/span><span lang=\"fr-FR\">p<\/span>1 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b4\u03b9\u03b1\u03bc\u03b5\u03c3\u03bf\u03bb\u03ac\u03b2\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd <span lang=\"en-US\">POMC<\/span>.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a3\u03b5 \u03b5\u03c0\u03af\u03bc\u03c5\u03b5\u03c2 <span lang=\"en-US\">wister<\/span> <span lang=\"en-US\">rats<\/span> \u03b4\u03cc\u03b8\u03b7\u03ba\u03b5 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03bb\u03ae\u03c8\u03b7 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2, \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03bb\u03c5\u03ba\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03b5\u03c1\u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1. \u03a3\u03c5\u03b3\u03c7\u03c1\u03cc\u03bd\u03c9\u03c2 \u03bc\u03b5\u03bb\u03b5\u03c4\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b7 \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ce\u03bd \u03c4\u03bf\u03c5 <span lang=\"en-US\">NpY<\/span> \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 <span lang=\"en-US\">POMC<\/span>. \u03a4\u03bf \u039d\u03a1\u03a5 \u03b4\u03b5\u03bd \u03b5\u03af\u03c7\u03b5 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7\u03c2. \u03a3\u03c4\u03b7\u03bd <span lang=\"en-US\">POMC<\/span> \u03b5\u03c5\u03c1\u03ad\u03b8\u03b7 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd <span lang=\"en-US\">CpG<\/span> 156-152 \u03b1\u03bd\u03ac\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 <span lang=\"en-US\">S<\/span><span lang=\"fr-FR\">p<\/span>1 \u03ba\u03b1\u03b9 \u039d<span lang=\"en-US\">F<\/span>&#8211;<span lang=\"en-US\">kB<\/span>. \u0397 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7\u03c2 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03bd \u03bd\u03b1 \u03b5\u03be\u03b7\u03b3\u03b7\u03b8\u03b5\u03af \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03b3\u03bb\u03c5\u03ba\u03b1\u03b9\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 <span style=\"font-family: AdvPSSAB-R, 'Times New Roman', serif;\"><span lang=\"es-ES\">DNA<\/span><\/span> <span style=\"font-family: AdvPSSAB-R, 'Times New Roman', serif;\"><span lang=\"es-ES\">methyl transferase<\/span><\/span><span style=\"font-family: AdvPSSAB-R, 'Times New Roman', serif;\"> (<\/span><span style=\"font-family: AdvPSSAB-R, 'Times New Roman', serif;\"><span lang=\"es-ES\">DNMT<\/span><\/span><span style=\"font-family: AdvPSSAB-R, 'Times New Roman', serif;\">)<\/span>. \u0397 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 <span lang=\"en-US\">POMC<\/span> \u03ba\u03b1\u03b9 \u03ac\u03c1\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c1\u03b5\u03be\u03b9\u03bf\u03b3\u03cc\u03bd\u03bf \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bb\u03ae\u03c8\u03b7 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 (5).<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0397 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03bb\u03b9\u03bd\u03bf\u03bb\u03b5\u03ca\u03ba\u03bf\u03cd \u03bf\u03be\u03ad\u03c9\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03ba\u03cd\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03c0\u03c1\u03bf\u03ba\u03ac\u03bb\u03b5\u03c3\u03b5 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bb\u03ae\u03c8\u03b7\u03c2 \u03c6\u03b1\u03b3\u03b7\u03c4\u03bf\u03cd \u03c3\u03c4\u03b1 \u03bd\u03b5\u03bf\u03b3\u03ad\u03bd\u03bd\u03b7\u03c4\u03b1, \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 <span lang=\"en-US\">CpG<\/span> -100 \u03ba\u03b1\u03b9 -103 \u03c4\u03b7\u03c2 \u03c4\u03bf\u03c0\u03bf\u03b8\u03b5\u03c3\u03af\u03b1\u03c2 <span lang=\"en-US\">Sp<\/span>1 \u03c4\u03bf\u03c5 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae \u03c4\u03b7\u03c2 <span lang=\"en-US\">POMC<\/span> \u03ba\u03b1\u03b9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 <span lang=\"en-US\">POMC<\/span> (6).<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a7\u03bf\u03c1\u03b7\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c5\u03c0\u03b5\u03c1\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03af\u03b1\u03b9\u03c4\u03b1 \u03c3\u03b5 \u03b8\u03b7\u03bb\u03c5\u03ba\u03bf\u03cd\u03c2 \u03b5\u03c0\u03af\u03bc\u03c5\u03b5\u03c2 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bd\u03b1 \u03b1\u03c5\u03be\u03b7\u03b8\u03b5\u03af \u03c4\u03bf \u03b2\u03ac\u03c1\u03bf\u03c2 \u03c4\u03bf\u03c5\u03c2, \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03c3\u03bf\u03c5\u03bd \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae \u03c4\u03b7\u03c2 <span lang=\"en-US\">POMC<\/span> \u03c3\u03c4\u03b9\u03c2 \u03b8\u03ad\u03c3\u03b5\u03b9\u03c2 -202, -166 \u03ba\u03b1\u03b9 -164 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 <span lang=\"en-US\">mRNA<\/span> \u03c4\u03b7\u03c2 <span lang=\"en-US\">POMC<\/span>. \u03a3\u03b5 \u03cc\u03c3\u03bf\u03c5\u03c2 \u03b8\u03b7\u03bb\u03c5\u03ba\u03bf\u03cd\u03c2 \u03b5\u03c0\u03af\u03bc\u03c5\u03b5\u03c2 \u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b5 \u03ba\u03cd\u03b7\u03c3\u03b7 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03bf \u03c4\u03ad\u03bb\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b3\u03b1\u03bb\u03bf\u03c5\u03c7\u03af\u03b1\u03c2 \u03b1\u03c0\u03bf\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c4\u03b1 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 <span lang=\"en-US\">mRNA<\/span> \u03c4\u03b7\u03c2 <span lang=\"en-US\">POMC<\/span>, \u03b5\u03bd\u03ce \u03c0\u03b1\u03c1\u03ad\u03bc\u03b5\u03bd\u03b5 \u03ad\u03bd\u03b1 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ac \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03b2\u03ac\u03c1\u03bf\u03c2. \u03a4\u03b1 \u03bd\u03b5\u03bf\u03b3\u03ad\u03bd\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03bc\u03b7\u03c4\u03ad\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03ad\u03bb\u03b1\u03b2\u03b1\u03bd \u03c5\u03c0\u03b5\u03c1\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03af\u03b1\u03b9\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03ba\u03cd\u03b7\u03c3\u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b1\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03cc\u03c1\u03b5\u03be\u03b7, \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03b2\u03ac\u03c1\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae \u03c4\u03b7\u03c2 <span lang=\"en-US\">POMC<\/span> \u03c3\u03c4\u03b9\u03c2 \u03b8\u03ad\u03c3\u03b5\u03b9\u03c2 -224, -202, -192, -164, -125 (7).<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a3\u03b5 \u03bd\u03b5\u03bf\u03b3\u03ad\u03bd\u03bd\u03b7\u03c4\u03bf\u03c5\u03c2 \u03b5\u03c0\u03af\u03bc\u03c5\u03b5\u03c2 <span lang=\"en-US\">Wister<\/span> <span lang=\"en-US\">rats<\/span> \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03c0\u03bb\u03bf\u03cd\u03c3\u03b9\u03b1 \u03c3\u03b5 \u03bb\u03b9\u03c0\u03b1\u03c1\u03ac \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 <span lang=\"en-US\">CpG<\/span> -166 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03b1\u03bd\u03ac\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 <span lang=\"en-US\">Sp<\/span>1 \u03c4\u03bf\u03c5 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae \u03c4\u03b7\u03c2 <span lang=\"fr-FR\">PO<\/span><span lang=\"en-US\">MC<\/span><\/p>\n<p class=\"western\" lang=\"el-GR\">\u038c\u03c3\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 <u>\u03b5\u03af\u03c7\u03b1\u03bd \u03bb\u03ac\u03b2\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7<\/u> (\u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03b7\u03b3\u03b7\u03b8\u03b5\u03af\u03c3\u03b7\u03c2 \u03b3\u03b1\u03bb\u03bf\u03c5\u03c7\u03af\u03b1\u03c2) \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b1\u03bd \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1 \u03c5\u03c0\u03bf\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 <span lang=\"fr-FR\">PO<\/span><span lang=\"en-US\">MC<\/span>. \u0391\u03c5\u03c4\u03cc \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b2\u03b1\u03b8\u03bc\u03cc \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 <span lang=\"en-US\">POMC<\/span> (8).<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a5\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03ba\u03cd\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03ba\u03ac\u03bb\u03b5\u03c3\u03b5 \u03c5\u03c0\u03bf\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 <span lang=\"en-US\">POMC<\/span> (9).<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1: \u039f\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03c5\u03bc\u03c6\u03c9\u03bd\u03bf\u03cd\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae \u03c4\u03b7\u03c2 <span lang=\"en-US\">POMC<\/span> \u03ba\u03b1\u03b9 \u03ac\u03c1\u03b1 \u03c3\u03b5 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2, \u03ac\u03c1\u03b1 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c1\u03b5\u03be\u03b9\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c0\u03bf\u03bb\u03c5\u03c6\u03b1\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03bb\u03ae\u03c8\u03b7 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2.<\/p>\n<p class=\"western\" lang=\"el-GR\"><span lang=\"en-US\"><b>GCR<\/b><\/span><b> \u03a5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03b3\u03bb\u03c5\u03ba\u03bf\u03ba\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd<\/b><\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a4\u03b1 \u03b3\u03bb\u03c5\u03ba\u03bf\u03ba\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03b5\u03b9\u03b4\u03ae \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b8\u03ac\u03bb\u03b1\u03bc\u03bf \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c1\u03b5\u03be\u03b9\u03bf\u03b3\u03cc\u03bd\u03bf \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 <span lang=\"en-US\">POMC<\/span> \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03bf\u03c1\u03b5\u03be\u03b9\u03bf\u03b3\u03cc\u03bd\u03bf \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03bf\u03c5 \u039d\u03a1\u03a5 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bb\u03ae\u03c8\u03b7\u03c2 \u03c6\u03b1\u03b3\u03b7\u03c4\u03bf\u03cd.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u039c\u03b5\u03af\u03c9\u03c3\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ac \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2 \u03c3\u03b5 \u03ad\u03b3\u03ba\u03c5\u03b5\u03c2 \u03c0\u03c1\u03bf\u03b2\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03c0\u03c1\u03bf\u03ba\u03ac\u03bb\u03b5\u03c3\u03b5 \u03c5\u03c0\u03bf\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03c9\u03bd \u03b3\u03bb\u03c5\u03ba\u03bf\u03ba\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd <span lang=\"en-US\">GR<\/span>, \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 <span lang=\"en-US\">POMC<\/span>, \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03cc\u03c1\u03b5\u03be\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03bb\u03ae\u03c8\u03b7 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 (10).<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a5\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03b8\u03b7\u03bb\u03c5\u03ba\u03ce\u03bd \u03b5\u03c0\u03af\u03bc\u03c5\u03c9\u03bd \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03ba\u03cd\u03b7\u03c3\u03b7 \u03c0\u03c1\u03bf\u03ba\u03ac\u03bb\u03b5\u03c3\u03b5 \u03c5\u03c0\u03bf\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03c9\u03bd \u03b3\u03bb\u03c5\u03ba\u03bf\u03ba\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd <span lang=\"en-US\">GR<\/span> \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03be\u03c9\u03bd\u03af\u03bf\u03c5 1<sub>10<\/sub> \u03c3\u03c4\u03b1 \u03bd\u03b5\u03bf\u03b3\u03ad\u03bd\u03b7\u03c4\u03b1, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03c0\u03b5\u03c6\u03b5\u03cd\u03c7\u03b8\u03b7 \u03cc\u03c4\u03b1\u03bd \u03bf\u03b9 \u03ad\u03b3\u03ba\u03c5\u03b5\u03c2 \u03b5\u03bb\u03ac\u03bc\u03b2\u03b1\u03bd\u03b1\u03bd \u03c6\u03bf\u03bb\u03b9\u03ba\u03cc \u03bf\u03be\u03cd (11).<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a5\u03c0\u03bf\u03b8\u03b5\u03c1\u03bc\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03af\u03b1\u03b9\u03c4\u03b1 \u03c3\u03b5 \u03ad\u03b3\u03ba\u03c5\u03b5\u03c2 \u03c0\u03c1\u03bf\u03b2\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03c0\u03c1\u03bf\u03ba\u03ac\u03bb\u03b5\u03c3\u03b5 \u03c5\u03c0\u03bf\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03c9\u03bd \u03b3\u03bb\u03c5\u03ba\u03bf\u03ba\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd <span lang=\"en-US\">GR<\/span>, \u03c5\u03c0\u03bf\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03c3\u03c4\u03cc\u03bd\u03b7\u03c2 \u03c3\u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 \u03bb\u03c5\u03c3\u03af\u03bd\u03b7 27 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03b5\u03c1\u03b1\u03ba\u03b5\u03c4\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03c3\u03c4\u03cc\u03bd\u03b7\u03c2 \u03973 \u03c3\u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 \u03bb\u03c5\u03c3\u03af\u03bd\u03b7 9 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b8\u03ac\u03bb\u03b1\u03bc\u03bf, \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03bc\u03b5 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 <span lang=\"en-US\">GR<\/span> <span lang=\"en-US\">mRNA<\/span> \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03c4\u03c9\u03bd 5 \u03b5\u03c4\u03ce\u03bd (12).<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1: \u03a6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c5\u03c0\u03bf\u03b8\u03b5\u03c1\u03bc\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03c0\u03c1\u03bf\u03b2\u03ac\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03c5\u03c0\u03bf\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03c4\u03c9\u03bd \u03ba\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd, \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2, \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03c1\u03b5\u03be\u03b9\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5\u03c2, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bb\u03ae\u03c8\u03b7 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2.<\/p>\n<p class=\"western\" lang=\"el-GR\"><b>\u039b\u03b5\u03c0\u03c4\u03af\u03bd\u03b7<\/b><\/p>\n<p class=\"western\" lang=\"el-GR\">\u0397 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b8\u03ac\u03bb\u03b1\u03bc\u03bf \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c1\u03b5\u03be\u03b9\u03bf\u03b3\u03cc\u03bd\u03bf \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 <span lang=\"en-US\">POMC<\/span> \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd \u03bf\u03c1\u03b5\u03be\u03b9\u03bf\u03b3\u03cc\u03bd\u03bf \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03bf\u03c5 \u039d\u03a1\u03a5 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bb\u03ae\u03c8\u03b7\u03c2 \u03c6\u03b1\u03b3\u03b7\u03c4\u03bf\u03cd. \u03a3\u03c4\u03b1 \u03c0\u03c1\u03bf\u03bb\u03b9\u03c0\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b7 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03bc\u03b9\u03ba\u03c1\u03ae \u03b5\u03bd\u03ce \u03c3\u03c4\u03b1 \u03ce\u03c1\u03b9\u03bc\u03b1 \u03bb\u03b9\u03c0\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c5\u03c0\u03bf\u03bc\u03b5\u03b8\u03c5\u03bb\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a5\u03c0\u03b5\u03c1\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03af\u03b1\u03b9\u03c4\u03b1 \u03c3\u03b5 \u03b5\u03c0\u03af\u03bc\u03c5\u03b5\u03c2 <span lang=\"en-US\">Wister<\/span> <span lang=\"en-US\">rats<\/span> \u03c0\u03c1\u03bf\u03ba\u03ac\u03bb\u03b5\u03c3\u03b5 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 <span lang=\"en-US\">CpG<\/span> -443 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03ce\u03c4\u03b5\u03c1\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae \u03c4\u03b7\u03c2 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2, \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03c0\u03c4\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03bb\u03ae\u03c8\u03b7 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 (13).<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03bf\u03ba\u03ac\u03bb\u03b5\u03c3\u03b5 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 2 \u03c3\u03c4\u03b7\u03bd \u03c4\u03bf\u03c0\u03bf\u03b8\u03b5\u03c3\u03af\u03b1\u03c2 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2 (<span lang=\"en-US\">BDM<\/span>2) \u03c4\u03bf\u03c5 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae \u03c4\u03b7\u03c2 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2, \u03c5\u03c0\u03bf\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03c3\u03c4\u03cc\u03bd\u03b7\u03c2 \u03c3\u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bb\u03c5\u03c3\u03af\u03bd\u03b7 4 (\u03973\u039a4) \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b1\u03ba\u03b5\u03c4\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03c3\u03c4\u03cc\u03bd\u03b7\u03c2 \u03973 \u03ba\u03b1\u03b9 \u03974 (14)<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a5\u03c0\u03b5\u03c1\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03ba\u03cd\u03b7\u03c3\u03b7 \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03bf\u03ba\u03ac\u03bb\u03b5\u03c3\u03b5 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03c3\u03c4\u03cc\u03bd\u03b7\u03c2 \u03974 \u03c3\u03c4\u03b7\u03bd \u03b8\u03ad\u03c3\u03b7 \u03bb\u03c5\u03c3\u03af\u03bd\u03b7 20 \u03c4\u03bf\u03c5 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae \u03c4\u03b7\u03c2 \u039b\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b1\u03ba\u03b5\u03c4\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03c3\u03c4\u03cc\u03bd\u03b7\u03c2 \u03973 \u03c3\u03c4\u03b7\u03bd \u03b8\u03ad\u03c3\u03b7 \u03bb\u03c5\u03c3\u03af\u03bd\u03b7 9 \u03c4\u03bf\u03c5 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae \u03c4\u03b7\u03c2 \u03b1\u03b4\u03b9\u03c0\u03bf\u03bd\u03b5\u03ba\u03c4\u03af\u03bd\u03b7\u03c2. \u03a0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03ba\u03b1\u03c4\u03b5\u03b3\u03c1\u03ac\u03c6\u03b7 \u03bb\u03ae\u03c8\u03b7 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03c3\u03c4\u03b1 \u03bd\u03b5\u03bf\u03b3\u03bd\u03ac (15).<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a5\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03ba\u03cd\u03b7\u03c3\u03b7 \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03bf\u03ba\u03ac\u03bb\u03b5\u03c3\u03b5 \u03c5\u03c0\u03bf\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd <span lang=\"en-US\">CpG<\/span> 7-17 \u03c4\u03bf\u03c5 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae \u03c4\u03b7\u03c2 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2, \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 <span lang=\"en-US\">mRNA<\/span> \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2 \u03c3\u03c4\u03bf\u03bd \u03bb\u03b9\u03c0\u03ce\u03b4\u03b7 \u03b9\u03c3\u03c4\u03cc, \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03b2\u03ac\u03c1\u03bf\u03c2 \u03bd\u03b5\u03bf\u03b3\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03bb\u03ae\u03c8\u03b7 \u03c6\u03b1\u03b3\u03b7\u03c4\u03bf\u03cd (16).<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a5\u03c0\u03bf\u03b8\u03b5\u03c1\u03bc\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03af\u03b1\u03b9\u03c4\u03b1 \u03c0\u03b1\u03c7\u03c5\u03c3\u03ac\u03c1\u03ba\u03c9\u03bd \u03b3\u03c5\u03bd\u03b1\u03b9\u03ba\u03ce\u03bd \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03c3\u03c4\u03bf\u03bd \u03bb\u03b9\u03c0\u03ce\u03b4\u03b7 \u03b9\u03c3\u03c4\u03cc \u03c5\u03c0\u03bf\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae \u03c4\u03b7\u03c2 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 <span lang=\"en-US\">TNF<\/span>-\u03b1 \u03c3\u03c4\u03bf\u03bd \u03bb\u03b9\u03c0\u03c9\u03b4\u03b7 \u03b9\u03c3\u03c4\u03cc, \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bc\u03c9\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 <span lang=\"en-US\">TNF<\/span>-\u03b1 (17).<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1: \u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03c5\u03bc\u03c6\u03c9\u03bd\u03bf\u03cd\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03c3\u03b5 \u03bb\u03ae\u03c8\u03b7 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2, \u03c7\u03c9\u03c1\u03af\u03c2 \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03bd\u03b1 \u03b1\u03bd\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03c4\u03b1\u03b9 \u03be\u03b5\u03ba\u03ac\u03b8\u03b1\u03c1\u03b1 \u03b7 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03bb\u03ae\u03c8\u03b7 \u03c4\u03c1\u03bf\u03c6\u03ae\u03c2. \u0391\u03bd\u03b1\u03bc\u03ad\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03bf \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf.<\/p>\n<p class=\"western\" lang=\"el-GR\"><b>\u03b1-<\/b><span lang=\"en-US\"><b>MSH<\/b><\/span><b> <\/b><span lang=\"en-US\"><b>MCR<\/b><\/span><b>4<\/b><\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a4\u03bf \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03cc \u03b1\u03b3\u03ba\u03bf\u03cd\u03c4\u03b9 (\u03b1\u03c1\u03bf\u03c5\u03c1\u03b1\u03af\u03bf\u03c2 \u039a\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u0391\u03bc\u03b5\u03c1\u03b9\u03ba\u03ae\u03c2) \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c4\u03bf \u03c7\u03c1\u03c9\u03bc\u03cc\u03c3\u03c9\u03bc\u03b1 2 \u03ad\u03bd\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03c0\u03bf\u03c5 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u0391\u03b3\u03ba\u03bf\u03cd\u03c4\u03b9 \u0391, \u03c0\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c4\u03bc\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1-<span lang=\"en-US\">MSH<\/span> \u03c4\u03b7\u03c2 <span lang=\"en-US\">POMC<\/span> (\u03c0\u03c1\u03bf\u03bf\u03c0\u03b9\u03bf\u03bc\u03b5\u03bb\u03b1\u03bd\u03bf\u03ba\u03bf\u03c1\u03c4\u03af\u03bd\u03b7\u03c2) \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 <span lang=\"en-US\">MCR<\/span>1 \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c7\u03c1\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c4\u03bf\u03c5 \u03c4\u03c1\u03b9\u03c7\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 <span lang=\"en-US\">MCR<\/span>4, \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03ba\u03bf\u03c1\u03b5\u03c3\u03bc\u03cc. \u0388\u03bd\u03b1 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03cc \u03ac\u03b3\u03c1\u03b9\u03bf \u03b1\u03b3\u03ba\u03bf\u03cd\u03c4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c3\u03c4\u03b1\u03bd\u03cc.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u039f \u03b1\u03bb\u03bb\u03b7\u03bb\u03cc\u03bc\u03bf\u03c1\u03c6\u03bf\u03c2 A<span lang=\"en-US\">v<\/span>y \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03b5\u03bd\u03cc\u03c2 <span lang=\"en-US\">CpG<\/span> \u03c4\u03bf\u03c5 <span lang=\"en-US\">promoter<\/span> \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u0391\u03b3\u03ba\u03bf\u03cd\u03c4\u03b9 \u0391 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03cc \u03ba\u03af\u03c4\u03c1\u03b9\u03bd\u03bf \u03bc\u03b5 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03ba\u03bf\u03c1\u03b5\u03c3\u03bc\u03cc, \u03ac\u03c1\u03b1 \u03c0\u03b1\u03c7\u03cd\u03c3\u03b1\u03c1\u03ba\u03bf \u03bb\u03cc\u03b3\u03c9 \u03c5\u03c0\u03b5\u03c1\u03c6\u03b1\u03b3\u03af\u03b1\u03c2. \u0391\u03bd \u03c5\u03c0\u03bf\u03b2\u03bf\u03b7\u03b8\u03ae\u03c3\u03bf\u03c5\u03bc\u03b5 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7, \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03af\u03bd\u03b7\u03c2 \u03b1\u03b3\u03ba\u03bf\u03cd\u03c4\u03b9 \u0391, \u03bf\u03c0\u03cc\u03c4\u03b5 \u03b7 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1-\u039c<span lang=\"en-US\">SH<\/span> \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 2 \u03c4\u03cd\u03c0\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c0\u03ac\u03bb\u03b9 \u03b5\u03c6\u03b9\u03ba\u03c4\u03ae \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c8\u03b5\u03c5\u03b4\u03bf\u03b1\u03b3\u03ba\u03bf\u03cd\u03c4\u03b9 \u03bc\u03b5 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03cc \u03ba\u03bf\u03c1\u03b5\u03c3\u03bc\u03cc, \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c7\u03c1\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03c3\u03c4\u03b1\u03bd\u03bf\u03cd.<\/p>\n<p class=\"western\" lang=\"el-GR\"><b>\u039c<\/b><span lang=\"en-US\"><b>C<\/b><\/span><b>4<\/b><span lang=\"en-US\"><b>R<\/b><\/span><\/p>\n<p class=\"western\" lang=\"el-GR\">\u0391\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c3\u03b5 \u03bb\u03af\u03c0\u03bf\u03c2 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae (&gt;45%) \u03bd\u03b5\u03bf\u03b3\u03bd\u03ce\u03bd \u03c0\u03b1\u03c7\u03cd\u03c3\u03b1\u03c1\u03ba\u03c9\u03bd \u03c0\u03bf\u03bd\u03c4\u03b9\u03ba\u03b9\u03ce\u03bd <span lang=\"en-US\">obese<\/span> <span lang=\"en-US\">Berlin<\/span> <span lang=\"en-US\">fat<\/span> <span lang=\"en-US\">mouse<\/span> (<span lang=\"en-US\">BFMI<\/span>) \u03c0\u03c1\u03bf\u03ba\u03ac\u03bb\u03b5\u03c3\u03b5 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae\u03c2 \u0399\u0399 \u03c0\u03bb\u03b7\u03c3\u03b9\u03ad\u03c3\u03c4\u03b5\u03c1\u03b7\u03c2 \u03c3\u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03c4\u03bf\u03c5 \u039c<span lang=\"en-US\">C<\/span>4<span lang=\"en-US\">R<\/span>, \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03bc\u03b5 \u03bc\u03b9\u03ba\u03c1\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1, \u03b1\u03bd\u03bf\u03c1\u03b5\u03be\u03b9\u03bf\u03b3\u03cc\u03bd\u03bf \u03b4\u03c1\u03ac\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b5\u03bb\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bc\u03b9\u03ba\u03c1\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 (18).<\/p>\n<p class=\"western\"><b>RXR<\/b><\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a5\u03c0\u03bf\u03b8\u03b5\u03c1\u03bc\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03ba\u03cd\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u039f\u03bb\u03bb\u03b1\u03bd\u03b4\u03af\u03b1 \u03c3\u03c4\u03bf \u03c4\u03ad\u03bb\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b2\u0384 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03bf\u03c5 \u03c0\u03bf\u03bb\u03ad\u03bc\u03bf\u03c5 (<span lang=\"en-US\">Dutch<\/span> <span lang=\"en-US\">famine<\/span>) \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03bc\u03b5 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b7 \u03b6\u03c9\u03ae. \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03cc\u03c4\u03b9 \u03c5\u03c0\u03ae\u03c1\u03be\u03b5 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03c9\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u039f <span lang=\"en-US\">PPR<\/span>\u03b3 \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03af\u03b6\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03b4\u03b9\u03bc\u03b5\u03c1\u03ad\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c1\u03b5\u03c4\u03b9\u03bd\u03bf\u03ca\u03ba\u03cc \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 <span lang=\"en-US\">RXR<\/span>.<\/p>\n<p class=\"western\" lang=\"el-GR\"><span lang=\"en-US\">H<\/span> \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae 136355885+ \u03c3\u03c4\u03bf \u03c7\u03c1\u03c9\u03bc\u03cc\u03c3\u03c9\u03bc\u03b1 9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03bf\u03bd\u03c4\u03ac \u03c3\u03b5 \u03c4\u03bf\u03c0\u03bf\u03b8\u03b5\u03c3\u03af\u03b5\u03c2 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2 (<span lang=\"en-US\">binding<\/span> <span lang=\"en-US\">site<\/span>) \u03c4\u03bf\u03c5 <span lang=\"en-US\">RXR<\/span>, <span lang=\"en-US\">NF<\/span>&#8211;<span lang=\"en-US\">Kb<\/span> \u03ba\u03bb\u03c0. \u0397 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 <span lang=\"en-US\">RXR<\/span>\u0391 \u03c3\u03c4\u03bf\u03bd \u03bb\u03b9\u03c0\u03ce\u03b4\u03b7 \u03b9\u03c3\u03c4\u03cc \u03c0\u03b1\u03c7\u03cd\u03c3\u03b1\u03c1\u03ba\u03c9\u03bd \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u039c\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c3\u03b5 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03bf\u03bc\u03c6\u03ac\u03bb\u03b9\u03bf\u03c5 \u03bb\u03ce\u03c1\u03bf\u03c5 \u03b2\u03c1\u03b5\u03c6\u03ce\u03bd \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03bf\u03b9 \u03bc\u03b7\u03c4\u03ad\u03c1\u03b5\u03c2 \u03ad\u03bb\u03b1\u03b2\u03b1\u03bd \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03bc\u03b5 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c5\u03b4\u03b1\u03c4\u03b1\u03bd\u03b8\u03c1\u03ac\u03ba\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03c1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2, \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 <span lang=\"en-US\">RXRA<\/span> <span lang=\"en-US\">chr<\/span>9:136355885+ \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03c4\u03b1\u03bd \u03bc\u03b5 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03bb\u03b9\u03c0\u03ce\u03b4\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd \u03c4\u03c9\u03bd \u03c0\u03b1\u03b9\u03b4\u03b9\u03ce\u03bd \u03c3\u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03c4\u03c9\u03bd 9 \u03b5\u03c4\u03ce\u03bd (19).<\/p>\n<p class=\"western\" lang=\"el-GR\"><span lang=\"en-US\"><b>PGC-1<\/b><\/span><b>\u03b1<\/b><\/p>\n<p class=\"western\" lang=\"el-GR\"><span lang=\"en-US\">Peroxisome proliferator activator receptor-<\/span>\u03b3<span lang=\"en-US\"> coactivator 1<\/span><span lang=\"en-GB\">&#8211;<\/span>\u03b1<\/p>\n<p class=\"western\" lang=\"el-GR\"><span style=\"font-size: medium;\">PGC-1\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03cc\u03c2 \u03c3\u03c5\u03bd\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03ae\u03c2 &#8211; \u03c3\u03c5\u03bd\u03b4\u03b9\u03b5\u03b3\u03ad\u03c1\u03c4\u03b7\u03c2, \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd PPAR-\u03b3. <\/span><\/p>\n<p class=\"western\" lang=\"el-GR\"><span style=\"font-size: medium;\">\u0395\u03af\u03bd\u03b1\u03b9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03ae\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03b9\u03b1\u03ba\u03ce\u03bd \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ce\u03bd. <\/span><\/p>\n<p class=\"western\" lang=\"el-GR\"><span style=\"font-size: medium;\">\u03a3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03a3\u0394\u0399\u0399 \u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 PGC-1\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7. <\/span><\/p>\n<p class=\"western\" lang=\"el-GR\"><span style=\"font-size: medium;\">\u03a0\u03b1\u03bb\u03bc\u03b9\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b5\u03b1\u03c1\u03b9\u03ba\u03cc \u03bf\u03be\u03cd \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 PGC-1\u03b1 \u03c3\u03c4\u03b1 \u03bc\u03c5\u03ca\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd. \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1 \u03b7 \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03c1\u03bf\u03be\u03b5\u03bd\u03b5\u03af \u03c5\u03c0\u03bf\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf \u03c0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03bf \u03c3\u03b5 PGC-1\u03b1 <\/span><span style=\"font-size: medium;\"><span lang=\"en-US\">mRNA<\/span><\/span><span style=\"font-size: medium;\"> \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 PGC-1\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bc\u03cd\u03b5\u03c2 (20).<\/span><\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0397 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03ba\u03b1\u03b8\u03af\u03c3\u03c4\u03b1\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03b4\u03cd\u03c3\u03ba\u03bf\u03bb\u03b7 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03bf\u03bc\u03bf\u03b9\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03b8\u03bf\u03b4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b5\u03c1\u03b3\u03b1\u03c3\u03b9\u03ce\u03bd \u03c9\u03c2 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2:<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a5\u03c0\u03bf\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf: \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03bf (\u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ac, \u03c0\u03c1\u03cc\u03b2\u03b1\u03c4\u03b1), \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf\u03c2<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0394\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7: \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03b9\u03b4\u03b9\u03ba\u03ae, \u03c5\u03c0\u03b5\u03c1\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ae, \u03c5\u03c0\u03bf\u03b8\u03b5\u03c1\u03bc\u03b9\u03b4\u03b9\u03ba\u03ae, \u03c5\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03ae, \u03c0\u03bb\u03bf\u03cd\u03c3\u03b9\u03b1 \u03c3\u03b5 \u03c5\u03b4\u03b1\u03c4\u03ac\u03bd\u03b8\u03c1\u03b1\u03ba\u03b5\u03c2 \u03ba\u03bb\u03c0<\/p>\n<p class=\"western\" lang=\"el-GR\">\u039a\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1: \u03c5\u03c0\u03bf\u03b8\u03b1\u03bb\u03b1\u03bc\u03b9\u03ba\u03ac, \u03bb\u03b9\u03c0\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03bb\u03b5\u03c5\u03ba\u03ac \u03b1\u03b9\u03bc\u03bf\u03c3\u03c6\u03b1\u03af\u03c1\u03b9\u03b1 \u03ba\u03bb\u03c0<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0393\u03bf\u03bd\u03af\u03b4\u03b9\u03bf: <span lang=\"en-US\">POMC<\/span>, <span lang=\"en-US\">GCR<\/span>, \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7, <span lang=\"en-US\">TNF<\/span>\u03b1, <span lang=\"en-US\">RXR<\/span>, \u039c<span lang=\"en-US\">C<\/span>4<span lang=\"en-US\">R<\/span>, <span lang=\"en-US\">PPR<\/span>\u03b3, PGC-1\u03b1<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2: \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae\u03c2, \u03c0\u03bb\u03b7\u03c3\u03af\u03bf\u03bd \u03c4\u03bf\u03c5 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae \u03ba\u03bb\u03c0.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u039f\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b5\u03c2 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1\u03c4\u03af \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c5\u03bd\u03b1\u03c4\u03ae \u03b7 \u03b8\u03c5\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b8\u03b1\u03bb\u03b1\u03bc\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b5\u03b3\u03ba\u03b5\u03c6\u03ac\u03bb\u03bf\u03c5.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03be\u03b1\u03c7\u03b8\u03bf\u03cd\u03bd \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (\u03bb\u03b5\u03c5\u03ba\u03ac \u03b1\u03b9\u03bc\u03bf\u03c3\u03c6\u03b1\u03af\u03c1\u03b9\u03b1, \u03bb\u03b9\u03c0\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1). \u0391\u03c5\u03c4\u03cc \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03b5\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03be\u03b1\u03b3\u03c9\u03b3\u03ae \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03b3\u03b9\u03b1\u03c4\u03af \u03b1\u03c6\u2019 \u03b5\u03bd\u03cc\u03c2 \u03bf\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03bf\u03af \u201c\u03c0\u03b1\u03af\u03ba\u03c4\u03b5\u03c2\u201d \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7, <span lang=\"en-US\">GCR<\/span> \u03ba\u03b1\u03b9 <span lang=\"en-US\">POMC<\/span> \u03b4\u03b5\u03bd \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03bd \u03af\u03b4\u03b9\u03bf \u03c4\u03c1\u03cc\u03c0\u03bf \u03ba\u03b1\u03b9 \u03b1\u03c6\u2019 \u03b5\u03c4\u03ad\u03c1\u03bf\u03c5 \u03b4\u03b9\u03cc\u03c4\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03bd\u03cc\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c3\u03c5\u03b3\u03c7\u03c1\u03cc\u03bd\u03c9\u03c2 \u03c5\u03c0\u03bf\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ac\u03bb\u03bb\u03bf\u03c5 \u03b9\u03c3\u03c4\u03bf\u03cd.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u039f\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03c3\u03c4\u03bf \u03c0\u03b5\u03b4\u03af\u03bf \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b3\u03b5\u03bd\u03c9\u03bc\u03b9\u03ba\u03ae\u03c2, \u03c5\u03c0\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03af\u03b6\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03b1\u03c5\u03c4\u03ae \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03c3\u03b5 \u03bd\u03b7\u03c0\u03b9\u03b1\u03ba\u03cc \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf. \u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03bf\u03cd\u03c3\u03b1 \u03b1\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c0\u03bf\u03bb\u03cd \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b5\u03c2 \u03b1\u03bd\u03b1\u03ba\u03bf\u03b9\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03c3\u03b5 \u03c0\u03bf\u03bb\u03cd \u03bb\u03af\u03b3\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ae\u03b4\u03b7 \u03c0\u03b1\u03c1\u03c9\u03c7\u03b7\u03bc\u03ad\u03bd\u03b7.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u03a3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0397 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b3\u03b5\u03bd\u03c9\u03bc\u03b9\u03ba\u03ae, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03c9\u03bd \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03c9\u03bd \u03c4\u03c1\u03bf\u03c6\u03ce\u03bd \u03c3\u03c4\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf \u03bc\u03b5 \u03c4\u03bf\u03bd \u03bf\u03c0\u03bf\u03af\u03bf \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03ac \u03bc\u03b1\u03c2, \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03b5\u03b9 \u03c4\u03bf \u03c0\u03b5\u03b4\u03af\u03bf \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c3\u03c4\u03bf \u03ac\u03bc\u03b5\u03c3\u03bf \u03bc\u03ad\u03bb\u03bb\u03bf\u03bd.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0397 \u03b1\u03c0\u03bb\u03ae \u03b5\u03be\u03af\u03c3\u03c9\u03c3\u03b7 \u03c4\u03c1\u03ce\u03c9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf, \u03ac\u03c1\u03b1 \u03c0\u03b1\u03c7\u03b1\u03af\u03bd\u03c9, \u03c6\u03b1\u03bd\u03c4\u03ac\u03b6\u03b5\u03b9 \u03c0\u03bb\u03ad\u03bf\u03bd \u03b1\u03bd\u03b5\u03c0\u03b1\u03c1\u03ba\u03ae\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c5\u03b3\u03ae \u03c4\u03bf\u03c5 21<sup>\u03bf\u03c5<\/sup> \u03b1\u03b9\u03ce\u03bd\u03b1. \u0394\u03b5\u03bd \u03b5\u03af\u03bc\u03b1\u03c3\u03c4\u03b5 \u03cc\u03bb\u03bf\u03b9 \u03af\u03c3\u03bf\u03b9 \u03b1\u03c0\u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c3\u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03ac.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0397 \u03b1\u03bd\u03b9\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1 \u03cc\u03bc\u03c9\u03c2 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03b7\u03c2 \u03c4\u03c1\u03bf\u03c6\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1\u03c2 \u03b4\u03b5\u03bd \u03ad\u03b3\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03b1\u03c0\u03bb\u03ae \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03b3\u03b5\u03bd\u03bd\u03b9\u03ad\u03c4\u03b1\u03b9 \u03bf \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c6\u03ad\u03c1\u03b5\u03b9 \u03c9\u03c2 \u03b4\u03c5\u03c3\u03b2\u03ac\u03c3\u03c4\u03b1\u03c7\u03c4\u03bf \u03c6\u03bf\u03c1\u03c4\u03af\u03bf \u03c3\u03b5 \u03cc\u03bb\u03b7 \u03c4\u03bf\u03c5 \u03c4\u03b7 \u03b6\u03c9\u03ae, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b9\u03b1\u03bc\u03bf\u03c1\u03c6\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c4\u03c1\u03bf\u03c6\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b7\u03b8\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03c4\u03c1\u03ce\u03b5\u03b9 \u03b5\u03c0\u03af \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03cc\u03c2 \u03c4\u03bf\u03c5.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u039c\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03bb\u03cc\u03b3\u03b9\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c0\u03cc\u03c6\u03b5\u03c5\u03ba\u03c4\u03b7 \u03b7 \u03b5\u03b3\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1\u03c2, \u03b1\u03bb\u03bb\u03ac \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd \u03c4\u03c9\u03bd \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03ce\u03bd \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ce\u03bd \u03c4\u03bf\u03c5 \u03b1\u03c4\u03cc\u03bc\u03bf\u03c5.<\/p>\n<p class=\"western\" lang=\"el-GR\">\u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/p>\n<p class=\"western\" lang=\"el-GR\"><span lang=\"en-US\">1. Corella D <\/span><span lang=\"fr-FR\">e<\/span><span lang=\"en-US\">t al. Int J Obes (Lond). 2011 May;35(5):666-75. <\/span><\/p>\n<p class=\"western\">Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene-saturated fat interaction.<\/p>\n<p class=\"western\">2. Memisoglu A et al. Hum Mol Genet. 2003 Nov 15;12(22):2923-9.<\/p>\n<p class=\"western\">Interaction between a peroxisome proliferator-activated receptor gamma gene polymorphism and dietary fat intake in relation to body mass.<\/p>\n<p class=\"western\">3. Phillips CM et al. J Nutr. 2012 May;142(5):824-31.<\/p>\n<p class=\"western\">High dietary saturated fat intake accentuates obesity risk associated with the fat mass and obesity-associated gene in adults.<\/p>\n<p class=\"western\">4. Kilpel\u00e4inen TO et al. PLoS Med. 2011 Nov;8(11):e1001116.<\/p>\n<p class=\"western\">Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.<\/p>\n<p class=\"western\">5. J Physiol. 2009 Oct 15;587(Pt 20):4963-76. Plagemann A et al.<\/p>\n<p class=\"western\">Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome.<\/p>\n<p class=\"western\">6. Diabetes. 2014 May;63(5):1475-87. Zhang X et al.<\/p>\n<p class=\"western\">Hypermethylation of Sp1 binding site suppresses hypothalamic POMC in neonates and may contribute to metabolic disorders in adults: impact of maternal dietary CLAs.<\/p>\n<p class=\"western\">7. FASEB J. 2014 Jun 13. Marco A et al.<\/p>\n<p class=\"western\">Overweight and CpG methylation of the Pomc promoter in offspring of high-fat-diet-fed dams are not &#8220;reprogrammed&#8221; by regular chow diet in rats.<\/p>\n<p class=\"western\">8. Br J Nutr. 2011 Sep;106(5):769-78. Palou M. et al.<\/p>\n<p class=\"western\">Protective effects of leptin during the suckling period against later obesity may be associated with changes in promoter methylation of the hypothalamic pro-opiomelanocortin gene.<\/p>\n<p class=\"western\">9. Endocrinology. 2010 Feb;151(2):702-13. Coup\u00e9 B et al.<\/p>\n<p class=\"western\">Nutritional programming affects hypothalamic organization and early response to leptin.<\/p>\n<p class=\"western\">10. Endocrinology. 2010 Aug;151(8):3652-64. Stevens A et al.<\/p>\n<p class=\"western\">Epigenetic changes in the hypothalamic proopiomelanocortin and glucocorticoid receptor genes in the ovine fetus after periconceptional undernutrition.<\/p>\n<p class=\"western\">11. J Nutr. 2005 Jun;135(6):1382-6. Lillycrop KA et al.<\/p>\n<p class=\"western\">Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring.<\/p>\n<p class=\"western\">12. Endocrinology. 2013 Dec;154(12):4560-9. Begum G et al.<\/p>\n<p class=\"western\">Maternal undernutrition programs tissue-specific epigenetic changes in the glucocorticoid receptor in adult offspring.<\/p>\n<p class=\"western\">13. FASEB J. 2011 Apr;25(4):1378-89. Milagro F et al.<\/p>\n<p class=\"western\">A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss.<\/p>\n<p class=\"western\">14. Sci Rep. 2014 Jun 13;4:5282. Shen W et al. .<\/p>\n<p class=\"western\">Epigenetic modification of the leptin promoter in diet-induced obese mice and the effects of N-3 polyunsaturated fatty acids.<\/p>\n<p class=\"western\">15. Endocrinology. 2012 Jun;153(6):2823-30. Masuyama H et al.<\/p>\n<p class=\"western\">Effects of a high-fat diet exposure in utero on the metabolic syndrome-like phenomenon in mouse offspring through epigenetic changes in adipocytokine gene expression.<\/p>\n<p class=\"western\">16. FASEB J. 2011 Sep;25(9):3271-8. Jousse C et al.<\/p>\n<p class=\"western\">Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome.<\/p>\n<p class=\"western\">17. J Physiol Biochem. 2011 Sep;67(3):463-70. Cordero P et al.<\/p>\n<p class=\"western\">Leptin and TNF-alpha promoter methylation levels measured by MSP could predict the response to a low-calorie diet.<\/p>\n<p class=\"western\">18. J Appl Genet. 2010;51(2):193-7. Widiker S et al.<\/p>\n<p class=\"western\">High-fat diet leads to a decreased methylation of the Mc4r gene in the obese BFMI and the lean B6 mouse lines.<\/p>\n<p class=\"western\">19. Diabetes. 2011 May;60(5):1528-34. Godfrey KM et al.<\/p>\n<p class=\"western\">Epigenetic gene promoter methylation at birth is associated with child&#8217;s later adiposity.<\/p>\n<p class=\"western\">20. J Biol Chem. 2007 May 25;282(21):15439-50. Crunkhorn S et al.<\/p>\n<p class=\"western\">Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u03a7\u03ac\u03c1\u03b7\u03c2 \u039a\u03b1\u03bd\u03b4\u03b7\u03bb\u03ce\u03c1\u03bf\u03c2,\u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2,\u0394\u03b9\u03b1\u03b2\u03b7\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u0394\u03b9\u03b4\u03ac\u03ba\u03c4\u03c9\u03c1. \u03a4. \u03b5\u03c0\u03b9\u03bc\u03b5\u03bb\u03b7\u03c4\u03ae\u03c2 \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03af\u03bf\u03c5 Nancy harican@otenet.gr \u0393\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03cd\u03bb\u03b7\u03c0\u03c4\u03bf \u03c4\u03bf \u03c0\u03b1\u03c1\u03cc\u03bd \u03b8\u03ad\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03bf \u03c0\u03b5\u03b4\u03af\u03bf \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1\u03c2, \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b3\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2, \u03b3\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b3\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2&hellip;<\/p>\n<p class=\"more-link-p\"><a class=\"more-link\" href=\"https:\/\/armonia-zoi.gr\/%ce%b4%ce%b9%ce%b1%cf%84%cf%81%ce%bf%cf%86%ce%bf%ce%b3%ce%b5%ce%bd%ce%b5%cf%84%ce%b9%ce%ba%ce%ae-%ce%ba%ce%b1%ce%b9-%ce%b4%ce%b9%ce%b1%cf%84%cf%81%ce%bf%cf%86%ce%bf%ce%b3%ce%b5%ce%bd%cf%89%ce%bc%ce%b9\/\">Read more &rarr;<\/a><\/p>\n","protected":false},"author":34,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_newsletter_tier_id":0,"footnotes":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false}}},"categories":[34],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p4lxm8-eP","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/posts\/919"}],"collection":[{"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/users\/34"}],"replies":[{"embeddable":true,"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/comments?post=919"}],"version-history":[{"count":6,"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/posts\/919\/revisions"}],"predecessor-version":[{"id":939,"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/posts\/919\/revisions\/939"}],"wp:attachment":[{"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/media?parent=919"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/categories?post=919"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/tags?post=919"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}